Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 5/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.37 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.36 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.35 |
| ▸ | PRKCI | P41743 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16375219 | 0.75 | POLB (0.36) | ANO1ALDH1A1L3MBTL1CYP1A2CYP2C9 | |
| SCHEMBL30289758 | 0.74 | KMO (0.38) | ANO1ALDH1A1L3MBTL1TSHRCYP1A2 | |
| SCHEMBL16375222 | 0.74 | KMO (0.38) | ANO1ALDH1A1L3MBTL1TSHRCYP1A2 | |
| SCHEMBL5583675 | 0.66 | ALDH1A1 (0.48) | MAPK14NR1I2NPC1ALDH1A1GLA | |
| SCHEMBL9543299 | 0.65 | PDE4A (0.35) | ANO1NPC1ALDH1A1RAB9ATSHR | |
| SCHEMBL5491533 | 0.65 | ALDH1A1 (0.49) | ANO1NPC1ALDH1A1RAB9AHTT | |
| SCHEMBL31139989 | 0.65 | NUDT1 (0.30) | — | |
| SCHEMBL16375223 | 0.65 | SMN1; SMN2 (0.31) | — | |
| SCHEMBL26607478 | 0.64 | MAPT (0.50) | SERPINE1NPC1ALDH1A1GLARAB9A | |
| SCHEMBL26607445 | 0.64 | NPC1 (0.51) | PRKCINPC1ALDH1A1RAB9ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110698481-B | Heteroaryl pyridone and aza-pyridone amide compounds | 豪夫迈·罗氏有限公司 | 2023-02-28 | — | — | CN | disclosed |
| CN-110698481-A | Heteroaryl pyridone and aza-pyridone amide compounds | 豪夫迈·罗氏有限公司 | 2020-01-17 | — | — | CN | disclosed |
| US-9326985-B2 | Heteroaryl pyridone and aza-pyridone amide compounds | GENENTECH, INC. (US) | 2016-05-03 | — | — | US | disclosed |
| US-20150011461-A1 | HETEROARYL PYRIDONE AND AZA-PYRIDONE AMIDE COMPOUNDS | GENENTECH, INC. (US) | 2015-01-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150011461-A1 | HETEROARYL PYRIDONE AND AZA-PYRIDONE AMIDE COMPOUNDS | BTK, TYK2, LCK | MAPK14 516/4885MAPK13 1141/4885ANO1 4719/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.