Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 9/20 | 0.71 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.71 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.71 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.71 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.71 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.71 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.71 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.71 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.71 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.71 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.71 |
| ▸ | KDM1A | O60341 | 4/20 | 0.65 |
| ▸ | NPC1 | O15118 | 4/20 | 0.62 |
| ▸ | RAB9A | P51151 | 4/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3035750 | 0.87 | MAPT (0.61) | HDAC1HDAC6HDAC8HDAC2HDAC5 | |
| SCHEMBL3018285 | 0.86 | HDAC1 (0.63) | HDAC1HDAC6HDAC8HDAC2HDAC5 | |
| SCHEMBL3038715 | 0.86 | MMP13 (0.72) | HDAC1HDAC6HDAC8HDAC2HDAC5 | |
| SCHEMBL3031939 | 0.85 | NPC1 (0.80) | HDAC1HDAC6HDAC8HDAC2HDAC5 | |
| SCHEMBL3028816 | 0.84 | RAB9A (0.63) | HDAC1HDAC6HDAC8HDAC2HDAC5 | |
| SCHEMBL6195180 | 0.84 | NR1H4 (0.65) | HDAC1HDAC6HDAC8HDAC2HDAC5 | |
| SCHEMBL10207296 | 0.83 | HDAC6 (1.00) | HDAC1HDAC6HDAC8HDAC2HDAC5 | |
| SCHEMBL3035034 | 0.83 | HDAC6 (0.74) | HDAC1HDAC6HDAC8HDAC2HDAC5 | |
| SCHEMBL8291127 | 0.83 | HDAC1 (1.00) | HDAC1HDAC6HDAC8HDAC2HDAC5 | |
| SCHEMBL3035661 | 0.83 | MMP13 (0.76) | HDAC1HDAC6HDAC8HDAC2HDAC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100216796-A1 | N-HYDROXY-NAPHTHALENE DICARBOXAMIDE AND N-HYDROXY-BIPHENYL-DICARBOXAMIDE COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | KATTAR SOLOMON | 2010-08-26 | — | — | US | claimed |
| US-20100216796-A1 | N-HYDROXY-NAPHTHALENE DICARBOXAMIDE AND N-HYDROXY-BIPHENYL-DICARBOXAMIDE COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | KATTAR SOLOMON | 2010-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216796-A1 | N-HYDROXY-NAPHTHALENE DICARBOXAMIDE AND N-HYDROXY-BIPHENYL-DICARBOXAMIDE COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | BRDT, AADAC, ACIN1 | HDAC1 5/4885HDAC6 31/4885HDAC8 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.