Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CDC25B | P30305 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | SMO | Q99835 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | CMA1 | P23946 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22853399 | 1.00 | ALDH1A1 (0.45) | ALDH1A1L3MBTL1CDC25BKDM4EKMT2A | |
| SCHEMBL30294743 | 0.88 | ALDH1A1 (0.47) | ALDH1A1L3MBTL1KDM4EPOLBSMN1; SMN2 | |
| SCHEMBL22853396 | 0.88 | ALDH1A1 (0.47) | ALDH1A1L3MBTL1KDM4EPOLBSMN1; SMN2 | |
| SCHEMBL22852845 | 0.85 | KDM4E (0.46) | ALDH1A1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL30294776 | 0.85 | KDM4E (0.46) | ALDH1A1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL30294858 | 0.78 | CDC25B (0.48) | ALDH1A1CDC25BRXFP1CYP1A2CYP2C9 | |
| SCHEMBL22853040 | 0.78 | CDC25B (0.48) | ALDH1A1CDC25BRXFP1CYP1A2CYP2C9 | |
| SCHEMBL22853410 | 0.77 | CDC25B (0.47) | ALDH1A1CDC25BKDM4EKMT2APOLB | |
| SCHEMBL30294519 | 0.77 | CDC25B (0.47) | ALDH1A1CDC25BKDM4EKMT2APOLB | |
| SCHEMBL30294309 | 0.77 | CDC25B (0.47) | ALDH1A1CDC25BKDM4EKMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230103791-A1 | 2,3-DIHYDROQUINAZOLIN COMPOUNDS AS NAV1.8 INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2023-04-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230103791-A1 | 2,3-DIHYDROQUINAZOLIN COMPOUNDS AS NAV1.8 INHIBITORS | SCN8A, SCN1A, SCN1B | ALDH1A1 3102/4885L3MBTL1 2499/4885CDC25B 2843/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.