Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | APAF1 | O14727 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | CASP6 | P55212 | 1/20 | 0.46 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.46 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.46 |
| ▸ | SMO | Q99835 | 1/20 | 0.46 |
| ▸ | FABP4 | P15090 | 1/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.44 |
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30294776 | 1.00 | KDM4E (0.46) | KDM4EAPAF1RECQLCASP6CACNA1B | |
| SCHEMBL30294255 | 0.85 | ALDH1A1 (0.45) | KDM4ESMOMAPK10RXFP1MAPT | |
| SCHEMBL22853399 | 0.85 | ALDH1A1 (0.45) | KDM4ESMOMAPK10RXFP1MAPT | |
| SCHEMBL30294602 | 0.84 | TAS2R14 (0.49) | FABP4AKR1C3AKR1C2TAS2R14ALDH1A1 | |
| SCHEMBL22852844 | 0.84 | TAS2R14 (0.49) | FABP4AKR1C3AKR1C2TAS2R14ALDH1A1 | |
| SCHEMBL22853486 | 0.80 | MAPT (0.48) | KDM4EMAPK10RXFP1MAPTSMN1; SMN2 | |
| SCHEMBL30294677 | 0.80 | MAPT (0.48) | KDM4EMAPK10RXFP1MAPTSMN1; SMN2 | |
| SCHEMBL20639015 | 0.79 | SCN8A (0.47) | CA12CA1CA2CA7CA9 | |
| SCHEMBL425534 | 0.77 | CA12 (0.67) | KDM4EAKR1C3AKR1C2CA12CA1 | |
| SCHEMBL22853079 | 0.76 | MPO (0.57) | KDM4EAPAF1RECQLCASP6CACNA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020261114-A1 | 2,3-DIHYDROQUINAZOLIN COMPOUNDS AS NAV1.8 INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-12-30 | — | — | WO | disclosed |