Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS2R14 | Q9NYV8 | 3/20 | 0.51 |
| ▸ | MPO | P05164 | 4/20 | 0.50 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.45 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.45 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.45 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.45 |
| ▸ | ACLY | P53396 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | LIPC | P11150 | 1/20 | 0.43 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22852871 | 0.91 | MPO (0.57) | TAS2R14MPOGRIK1AKR1C3AKR1C2 | |
| SCHEMBL30294370 | 0.91 | MPO (0.57) | TAS2R14MPOGRIK1AKR1C3AKR1C2 | |
| SCHEMBL30294460 | 0.88 | CLCN2 (0.50) | MPOGRIK1AKR1C3AKR1C2AKR1B1 | |
| SCHEMBL22852848 | 0.88 | CLCN2 (0.50) | MPOGRIK1AKR1C3AKR1C2AKR1B1 | |
| SCHEMBL30294715 | 0.84 | KDM4E (0.42) | TAS2R14MPOKDM4ECYP2C19 | |
| SCHEMBL22853359 | 0.84 | KDM4E (0.42) | TAS2R14MPOKDM4ECYP2C19 | |
| SCHEMBL22853007 | 0.84 | CLCN2 (0.46) | GRIK1AKR1C3AKR1C2ACLYCLCN2 | |
| SCHEMBL30294254 | 0.84 | CLCN2 (0.46) | GRIK1AKR1C3AKR1C2ACLYCLCN2 | |
| SCHEMBL22833402 | 0.84 | TAS2R14 (0.61) | TAS2R14MPOGRIK1AKR1C3AKR1C2 | |
| SCHEMBL29380178 | 0.84 | TAS2R14 (0.61) | TAS2R14MPOGRIK1AKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230103791-A1 | 2,3-DIHYDROQUINAZOLIN COMPOUNDS AS NAV1.8 INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2023-04-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230103791-A1 | 2,3-DIHYDROQUINAZOLIN COMPOUNDS AS NAV1.8 INHIBITORS | SCN8A, SCN1A, SCN1B | TAS2R14 1406/4885MPO 3074/4885GRIK1 181/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.