Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 5/20 | 0.56 |
| ▸ | AKR1C2 | P52895 | 5/20 | 0.56 |
| ▸ | DHODH | Q02127 | 1/20 | 0.54 |
| ▸ | LIPC | P11150 | 1/20 | 0.52 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | APAF1 | O14727 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | CASP6 | P55212 | 1/20 | 0.51 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.51 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.51 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.51 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22853081 | 1.00 | AKR1C3 (0.56) | AKR1C3AKR1C2DHODHLIPCLIPG | |
| SCHEMBL22853079 | 0.88 | MPO (0.57) | AKR1C3AKR1C2DHODHLIPCLIPG | |
| SCHEMBL22853392 | 0.88 | DHODH (0.59) | AKR1C3AKR1C2DHODHLIPCLIPG | |
| SCHEMBL30294712 | 0.88 | MPO (0.57) | AKR1C3AKR1C2DHODHLIPCLIPG | |
| SCHEMBL30294477 | 0.88 | DHODH (0.59) | AKR1C3AKR1C2DHODHLIPCLIPG | |
| SCHEMBL22853044 | 0.85 | MAPT (0.49) | KDM4EMAPTLMNAKMT2ATSHR | |
| SCHEMBL30294496 | 0.85 | MAPT (0.49) | KDM4EMAPTLMNAKMT2ATSHR | |
| SCHEMBL31500249 | 0.85 | AKR1C3 (0.64) | AKR1C3AKR1C2DHODHMAPTMEN1 | |
| SCHEMBL3471637 | 0.83 | MAPT (0.57) | AKR1C3AKR1C2DHODHKDM4EMAPT | |
| SCHEMBL8834053 | 0.81 | AKR1C3 (0.63) | AKR1C3AKR1C2KDM4EAPAF1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230103791-A1 | 2,3-DIHYDROQUINAZOLIN COMPOUNDS AS NAV1.8 INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2023-04-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230103791-A1 | 2,3-DIHYDROQUINAZOLIN COMPOUNDS AS NAV1.8 INHIBITORS | SCN8A, SCN1A, SCN1B | AKR1C3 2437/4885AKR1C2 2468/4885DHODH 1951/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.