SCHEMBL3471637 — predicted protein targets

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	MAPT	P10636	5/20	0.57

▸	MEN1	O00255	4/20	0.57

▸	KMT2A	Q03164	4/20	0.57

▸	LMNA	P02545	2/20	0.57

▸	POLB	P06746	1/20	0.57

▸	AKR1C3	P42330	3/20	0.57

▸	AKR1C2	P52895	3/20	0.57

▸	CYP1A2	P05177	3/20	0.56

▸	CYP3A4	P08684	3/20	0.56

▸	CYP2C19	P33261	3/20	0.56

▸	CYP2D6	P10635	2/20	0.56

▸	FABP3	P05413	1/20	0.56

▸	FABP4	P15090	1/20	0.56

▸	HPGD	P15428	3/20	0.55

▸	GFER	P55789	1/20	0.55

▸	SMN1; SMN2	Q16637	1/20	0.55

▸	MPO	P05164	2/20	0.51

▸	TAS2R14	Q9NYV8	2/20	0.50

▸	DHODH	Q02127	1/20	0.50

▸	KCNK2	O95069	1/20	0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL30294635	0.83	AKR1C3 (0.56)	MAPTMEN1KMT2ALMNAPOLB
SCHEMBL30294477	0.83	DHODH (0.59)	MAPTMEN1KMT2ALMNAPOLB
SCHEMBL22853081	0.83	AKR1C3 (0.56)	MAPTMEN1KMT2ALMNAPOLB
SCHEMBL22853392	0.83	DHODH (0.59)	MAPTMEN1KMT2ALMNAPOLB
SCHEMBL22452471	0.82	MEN1 (0.63)	MAPTMEN1KMT2ALMNAPOLB
SCHEMBL22720113	0.80	MEN1 (0.72)	MAPTMEN1KMT2ALMNAPOLB
SCHEMBL31500249	0.80	AKR1C3 (0.64)	MAPTMEN1KMT2ALMNAPOLB
SCHEMBL330643	0.78	TMPRSS4 (0.69)	MAPTMEN1KMT2ACYP1A2CYP3A4
SCHEMBL7064381	0.77	AKR1C3 (0.65)	MAPTMEN1KMT2ALMNAPOLB
SCHEMBL6763103	0.76	CYP3A4 (0.61)	MAPTMEN1KMT2ALMNAPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-9211296-B2	Therapeutic compounds for blocking DNA synthesis of POX viruses	THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US)	2015-12-15	—	—	US	disclosed
US-9211296-B2	Therapeutic compounds for blocking DNA synthesis of POX viruses	THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US)	2015-12-15	—	—	US	disclosed
US-20130338117-A1	THERAPEUTIC COMPOUNDS FOR BLOCKING DNA SYNTHESIS OF POX VIRUSES	THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US)	2013-12-19	—	—	US	disclosed
US-8524719-B2	Therapeutic compounds for blocking DNA synthesis of pox viruses	THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US)	2013-09-03	—	—	US	disclosed
US-8524719-B2	Therapeutic compounds for blocking DNA synthesis of pox viruses	THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US)	2013-09-03	—	—	US	disclosed
US-8415393-B2	Anti-bacterial drug targeting of genome maintenance interfaces	WISCONSIN ALUMNI RESEARCH FOUNDATION (US)	2013-04-09	—	—	US	disclosed
US-8415393-B2	Anti-bacterial drug targeting of genome maintenance interfaces	WISCONSIN ALUMNI RESEARCH FOUNDATION (US)	2013-04-09	—	—	US	disclosed
US-8415393-B2	Anti-bacterial drug targeting of genome maintenance interfaces	WISCONSIN ALUMNI RESEARCH FOUNDATION (US)	2013-04-09	—	—	US	disclosed
US-20120322770-A1	THERAPEUTIC COMPOUNDS FOR BLOCKING DNA SYNTHESIS OF POX VIRUSES	NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT	2012-12-20	—	—	US	disclosed
US-8278342-B2	Therapeutic compounds for blocking DNA synthesis of pox viruses	THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US)	2012-10-02	—	—	US	disclosed
EP-2178532-A2	ANTI-BACTERIAL DRUG TARGETING OF GENOME MAINTENANCE INTERFACES	Wisconsin Alumni Research Foundation (US)	2010-04-28	—	—	EP	disclosed
US-20100035887-A1	THERAPEUTIC COMPOUNDS FOR BLOCKING DNA SYNTHESIS OF POX VIRUSES	NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT	2010-02-11	—	—	US	disclosed
US-20090203754-A1	ANTI-BACTERIAL DRUG TARGETING OF GENOME MAINTENANCE INTERFACES	WISCONSIN ALUMNI RESEARCH FOUNDATION	2009-08-13	—	—	US	disclosed
US-20090203754-A1	ANTI-BACTERIAL DRUG TARGETING OF GENOME MAINTENANCE INTERFACES	WISCONSIN ALUMNI RESEARCH FOUNDATION	2009-08-13	—	—	US	disclosed
US-20090203754-A1	ANTI-BACTERIAL DRUG TARGETING OF GENOME MAINTENANCE INTERFACES	WISCONSIN ALUMNI RESEARCH FOUNDATION	2009-08-13	—	—	US	disclosed
WO-2009023343-A2	ANTI-BACTERIAL DRUG TARGETING OF GENOME MAINTENANCE INTERFACES	WISCONSIN ALUMNI RESEARCH FOUNDATION (US)	2009-02-19	—	—	WO	disclosed
WO-2009023343-A2	ANTI-BACTERIAL DRUG TARGETING OF GENOME MAINTENANCE INTERFACES	WISCONSIN ALUMNI RESEARCH FOUNDATION (US)	2009-02-19	—	—	WO	disclosed
WO-2009008906-A2	THERAPEUTIC COMPOUNDS FOR BLOCKING DNA SYNTHESIS OF POX VIRUSES	THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US)	2009-01-15	—	—	WO	disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

Patent	Title	Text reads most about	Predicted target · text-rank
US-20120322770-A1	THERAPEUTIC COMPOUNDS FOR BLOCKING DNA SYNTHESIS OF POX VIRUSES	TPX2, POLB, POLM	MAPT 4220/4885MEN1 4101/4885KMT2A 3300/4885
US-20100035887-A1	THERAPEUTIC COMPOUNDS FOR BLOCKING DNA SYNTHESIS OF POX VIRUSES	TPX2, POLB, POLM	MAPT 4220/4885MEN1 4101/4885KMT2A 3300/4885
US-20090203754-A1	ANTI-BACTERIAL DRUG TARGETING OF GENOME MAINTENANCE INTERFACES	DDB1, DCLRE1B, POLM	MAPT 4348/4885MEN1 4066/4885KMT2A 4253/4885
US-20130338117-A1	THERAPEUTIC COMPOUNDS FOR BLOCKING DNA SYNTHESIS OF POX VIRUSES	TPX2, POLB, POLM	MAPT 4220/4885MEN1 4101/4885KMT2A 3300/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.