Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30295654 | 0.87 | ALDH1A1 (0.41) | SMN1; SMN2LMNAMAPTKMT2APOLB | |
| SCHEMBL30295656 | 0.86 | MAPT (0.34) | SMN1; SMN2MAPTHDAC6KMT2AROCK2 | |
| SCHEMBL24035813 | 0.83 | GLS (0.40) | HDAC6HDAC4 | |
| SCHEMBL30177510 | 0.81 | ALDH1A1 (0.37) | LMNAMAPTHDAC6KMT2AROCK2 | |
| SCHEMBL24035812 | 0.80 | HTT (0.44) | LMNAMAPTPTGER4ALDH1A1HPGD | |
| SCHEMBL24035386 | 0.79 | SMN1; SMN2 (0.37) | SMN1; SMN2LMNAMAPTHDAC6HDAC4 | |
| SCHEMBL24035888 | 0.77 | MAPT (0.38) | LMNAMAPTKMT2AROCK2ALDH1A1 | |
| SCHEMBL24035200 | 0.76 | CYP2D6 (0.40) | MAPTHDAC6ALDH1A1 | |
| SCHEMBL24035933 | 0.76 | MAPT (0.39) | LMNAMAPTHDAC6KMT2AROCK2 | |
| SCHEMBL30177453 | 0.75 | CYP2D6 (0.43) | HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4149459-A1 | METHODS AND COMPOUNDS FOR RESTORING MUTANT P53 FUNCTION | PMV Pharmaceuticals, Inc. (US) | 2023-03-22 | — | — | EP | disclosed |