Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | CNR2 | P34972 | 6/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.32 |
| ▸ | RORA | P35398 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | RORB | Q92753 | 1/20 | 0.32 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.32 |
| ▸ | PRKCG | P05129 | 1/20 | 0.32 |
| ▸ | PRKCB | P05771 | 1/20 | 0.32 |
| ▸ | PRKCA | P17252 | 1/20 | 0.32 |
| ▸ | PRKCH | P24723 | 1/20 | 0.32 |
| ▸ | PRKCI | P41743 | 1/20 | 0.32 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30295653 | 0.86 | SMN1; SMN2 (0.48) | MAPTHDAC6KMT2AROCK2SMN1; SMN2 | |
| SCHEMBL24035812 | 0.86 | HTT (0.44) | MAPTTP53CTNNB1GAAHTT | |
| SCHEMBL24852937 | 0.81 | CNR2 (0.34) | MAPTTP53CNR2HDAC1HDAC8 | |
| SCHEMBL24035276 | 0.81 | CNR2 (0.35) | MAPTTP53CNR2HDAC1HDAC8 | |
| SCHEMBL24035813 | 0.80 | GLS (0.40) | CNR2HDAC6 | |
| SCHEMBL30295654 | 0.80 | ALDH1A1 (0.41) | MAPTTP53KMT2ARXFP1ROCK2 | |
| SCHEMBL29065052 | 0.79 | MEN1 (0.32) | MEN1KMT2ARXFP1 | |
| SCHEMBL24035200 | 0.77 | CYP2D6 (0.40) | MAPTTP53CNR2HDAC6 | |
| SCHEMBL30177510 | 0.77 | ALDH1A1 (0.37) | MAPTTP53CNR2HDAC6KMT2A | |
| SCHEMBL24035596 | 0.75 | CCR2 (0.48) | RORARORCRORB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4149459-A1 | METHODS AND COMPOUNDS FOR RESTORING MUTANT P53 FUNCTION | PMV Pharmaceuticals, Inc. (US) | 2023-03-22 | — | — | EP | disclosed |