Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 3/20 | 0.35 |
| ▸ | EDNRB | P24530 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | C1R | P00736 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25084321 | 1.00 | EDNRA (0.35) | EDNRAEDNRBL3MBTL1P2RX7KMT2A | |
| SCHEMBL5525532 | 0.90 | EDNRA (0.37) | EDNRAEDNRBL3MBTL1P2RX7KMT2A | |
| SCHEMBL5398608 | 0.88 | L3MBTL1 (0.34) | EDNRAEDNRBL3MBTL1KMT2ATDP1 | |
| SCHEMBL27419205 | 0.88 | ALDH1A1 (0.32) | P2RX7ALDH1A1GAA | |
| SCHEMBL25289959 | 0.86 | EDNRA (0.39) | EDNRAEDNRBL3MBTL1P2RX7KMT2A | |
| SCHEMBL29281001 | 0.86 | P2RX7 (0.30) | P2RX7 | |
| SCHEMBL29281022 | 0.84 | ALDH1A1 (0.30) | ALDH1A1GAA | |
| SCHEMBL5392355 | 0.83 | EDNRA (0.34) | EDNRAEDNRBL3MBTL1KMT2ATDP1 | |
| SCHEMBL30844529 | 0.80 | EDNRB (0.35) | EDNRAEDNRBALDH1A1 | |
| SCHEMBL4774359 | 0.79 | EDNRA (0.34) | EDNRAEDNRBL3MBTL1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024175082-A1 | SALT CONTAINING AROMATIC RING DERIVATIVE ANTAGONIST, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | 江苏豪森药业集团有限公司 | 2024-08-29 | — | — | WO | disclosed |
| CN-118546134-A | Crystal form containing aromatic ring derivative antagonist, preparation method and application thereof | 江苏豪森药业集团有限公司 | 2024-08-27 | — | — | CN | disclosed |
| CN-117836294-A | Biological antagonist containing aromatic ring, preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2024-04-05 | — | — | CN | disclosed |
| WO-2023025277-A1 | AROMATIC RING-CONTAINING BIOLOGICAL ANTAGONIST, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 上海翰森生物医药科技有限公司 | 2023-03-02 | — | — | WO | disclosed |