Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | F11 | P03951 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26620077 | 1.00 | MAPT (0.36) | MAPTALDH1A1TSHRTHRBNPC1 | |
| SCHEMBL30983230 | 0.88 | MAPT (0.36) | MAPTALDH1A1THRBNPC1F11 | |
| SCHEMBL17548097 | 0.82 | DGAT1 (0.34) | MAPTNPC1SMN1; SMN2KDM4ERAB9A | |
| SCHEMBL26620126 | 0.80 | NPC1 (0.33) | MAPTNPC1DGAT1 | |
| SCHEMBL30296721 | 0.80 | NPC1 (0.33) | MAPTNPC1DGAT1 | |
| SCHEMBL30296875 | 0.79 | NPC1 (0.32) | MAPTNPC1DGAT1 | |
| SCHEMBL26620672 | 0.79 | NPC1 (0.32) | MAPTNPC1DGAT1 | |
| SCHEMBL30296488 | 0.79 | CYP11B2 (0.33) | NPC1DGAT1 | |
| SCHEMBL26620205 | 0.79 | CYP11B2 (0.33) | NPC1DGAT1 | |
| SCHEMBL17391654 | 0.78 | F11 (0.44) | MAPTTHRBNPC1F11SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4402143-A1 | SPIROCYCLIC COMPOUNDS | Astrazeneca AB (SE) | 2024-07-24 | — | — | EP | disclosed |
| CN-117916241-A | Spiro compounds | 阿斯利康(瑞典)有限公司 | 2024-04-19 | — | — | CN | disclosed |
| WO-2023036974-A1 | SPIROCYCLIC COMPOUNDS | ASTRAZENECA AB (SE) | 2023-03-16 | — | — | WO | disclosed |