Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PI4KA | P42356 | 1/20 | 0.39 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.39 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.39 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8942018 | 0.79 | TSHR (0.58) | ALDH1A1SMN1; SMN2MAPTTSHRNPC1 | |
| SCHEMBL1248063 | 0.77 | FLT3 (0.53) | ALDH1A1SMN1; SMN2MAPK1L3MBTL1 | |
| SCHEMBL17457925 | 0.71 | CYP2A6 (0.47) | CYP11B2SMN1; SMN2CYP2A6CYP3A4MAPT | |
| SCHEMBL17437518 | 0.70 | RPS6KA5 (0.50) | ALDH1A1MAPTTSHRHTTMAPK1 | |
| SCHEMBL16652179 | 0.70 | POLB (0.66) | CYP11B2ALDH1A1SMN1; SMN2CYP2A6CYP3A4 | |
| SCHEMBL7092394 | 0.70 | NPC1 (0.47) | KDM4EALDH1A1SMN1; SMN2MAPTHTT | |
| SCHEMBL15555920 | 0.70 | DHFR (0.43) | ALDH1A1MAPTTSHRRAB9AL3MBTL1 | |
| SCHEMBL16014624 | 0.69 | TSHR (0.47) | ALDH1A1SMN1; SMN2CYP3A4MAPTTSHR | |
| SCHEMBL6086847 | 0.69 | CYP11B2 (0.46) | CYP11B2CYP2A6CYP3A4PI4KAPI4K2B | |
| SCHEMBL12335152 | 0.69 | SMN1; SMN2 (0.57) | ALDH1A1SMN1; SMN2CYP2A6CYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116075303-A | Method of selecting patients treated with a combination of an AXL inhibitor and an immune checkpoint modulator | 卑尔根生物股份公司 | 2023-05-05 | — | — | CN | disclosed |
| CN-115916344-A | AXL inhibitors for antiviral therapy | 卑尔根生物股份公司 | 2023-04-04 | — | — | CN | disclosed |