Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 3/20 | 0.32 |
| ▸ | MTOR | P42345 | 2/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.30 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24088572 | 0.71 | KCNH2 (0.38) | ROCK2MTORPIK3CA | |
| SCHEMBL25753038 | 0.71 | BRD4 (0.39) | ADORA2AADORA2BADORA1 | |
| SCHEMBL732594 | 0.60 | TTK (0.37) | ROCK2 | |
| SCHEMBL24088570 | 0.59 | MAP3K5 (0.43) | — | |
| SCHEMBL22057992 | 0.59 | KCNH2 (0.37) | — | |
| SCHEMBL23780340 | 0.58 | GPR35 (0.36) | ROCK2MTORPIK3CA | |
| SCHEMBL3740850 | 0.57 | AKT2 (0.70) | ROCK2 | |
| SCHEMBL20995329 | 0.57 | AKT2 (0.47) | ROCK2 | |
| Hydrochloric Acid SCHEMBL30301426 | 0.57 | AKT2 (0.52) | — | |
| SCHEMBL9921839 | 0.57 | JAK2 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4157831-A1 | PROCESSES OF PREPARING A JAK1 INHIBITOR | Incyte Corporation (US) | 2023-04-05 | — | — | EP | disclosed |
| CN-115836065-A | Methods of making JAK1 inhibitors | 因赛特公司 | 2023-03-21 | — | — | CN | disclosed |