Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 4/20 | 0.39 |
| ▸ | HTR7 | P34969 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
| ▸ | AKT2 | P31751 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PDE2A | O00408 | 2/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24088572 | 0.82 | KCNH2 (0.38) | KCNH2AKT1AKT2LMNAAPEX1 | |
| SCHEMBL16200323 | 0.72 | ALDH1A1 (0.39) | KCNH2AKT1AKT2LMNAAPEX1 | |
| SCHEMBL14062350 | 0.72 | BRD4 (0.44) | BRD4HTR7HTR1APRMT5WDR77 | |
| SCHEMBL30301433 | 0.71 | ROCK2 (0.32) | ADORA2AADORA2BADORA1 | |
| SCHEMBL21241065 | 0.71 | PIM1 (0.42) | KCNH2AKT1AKT2LMNAAPEX1 | |
| SCHEMBL1423367 | 0.71 | PRMT5 (0.45) | BRD4HTR7HTR1APRMT5WDR77 | |
| SCHEMBL20320421 | 0.69 | MAPT (0.67) | BRD4HTR7HTR1AAKT2LMNA | |
| SCHEMBL12944870 | 0.69 | MAPT (0.47) | BRD4HTR7HTR1APRMT5WDR77 | |
| SCHEMBL21233196 | 0.69 | CYP11B2 (0.47) | BRD4KCNH2AKT1AKT2PRMT5 | |
| SCHEMBL4566614 | 0.69 | PDPK1 (0.44) | BRD4HTR7HTR1APRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11685731-B2 | Processes of preparing a JAK1 inhibitor | INCYTE CORPORATION (US) | 2023-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11685731-B2 | Processes of preparing a JAK1 inhibitor | JAK1, JAK2, JAK3 | BRD4 445/4885HTR7 2828/4885HTR1A 1428/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.