Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Guanadrel. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 3/20 | 0.40 |
| ▸ | HTR1A | P08908 | 3/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.39 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guanadrel SCHEMBL41051 | 1.00 | ADRA1D (0.40) | ADRA1DHTR1AADRA1BADRA1APABPC1 | |
| Guanadrel SCHEMBL1172913 | 0.93 | HTR1A (0.44) | ADRA1DHTR1AADRA1BADRA1APABPC1 | |
| Guanadrel SCHEMBL180963 | 0.93 | HTR1A (0.44) | ADRA1DHTR1AADRA1BADRA1APABPC1 | |
| Guanadrel SCHEMBL23858338 | 0.92 | HTR1A (0.43) | ADRA1DHTR1AADRA1BADRA1APABPC1 | |
| Guanadrel SCHEMBL1649864 | 0.75 | PABPC1 (0.40) | ADRA1DHTR1AADRA1BADRA1APABPC1 | |
| Guanadrel SCHEMBL23858296 | 0.75 | PABPC1 (0.40) | ADRA1DHTR1AADRA1BADRA1APABPC1 | |
| SCHEMBL20624944 | 0.68 | PABPC1 (0.51) | ADRA1DHTR1AADRA1BADRA1APABPC1 | |
| SCHEMBL21987642 | 0.68 | PABPC1 (0.47) | ADRA1DHTR1AADRA1BADRA1APABPC1 | |
| SCHEMBL8192982 | 0.67 | PABPC1 (0.53) | ADRA1DHTR1AADRA1BADRA1APABPC1 | |
| SCHEMBL1487109 | 0.67 | PABPC1 (0.53) | ADRA1DHTR1AADRA1BADRA1APABPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230218874-A1 | SWAB DELIVERY SYSTEM | ANERGENT PHARMACEUTICALS, INC. (US) | 2023-07-13 | — | — | US | disclosed |
| US-11623075-B2 | Buccal swab delivery system | ANERGENT PHARMACEUTICALS, INC. (US) | 2023-04-11 | — | — | US | disclosed |
| US-11607392-B2 | Encapsulation system for prolonged release of active agents | TREND INNOVATIONS (CA) | 2023-03-21 | — | — | US | disclosed |