Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL4954281 | 0.95 | TSHR (0.61) | TSHRUSP2TDP1HTTMAPT | |
| Propylene Glycol SCHEMBL55673 | 0.95 | TSHR (0.61) | TSHRUSP2TDP1HTTMAPT | |
| Propylene Glycol SCHEMBL28125539 | 0.93 | TSHR (0.58) | TSHRUSP2TDP1HTTMAPT | |
| Propylene Glycol SCHEMBL3930378 | 0.93 | TSHR (0.58) | TSHRUSP2TDP1HTTMAPT | |
| Propylene Glycol SCHEMBL23159879 | 0.91 | USP2 (0.59) | TSHRUSP2TDP1HTTMAPT | |
| Propylene Glycol SCHEMBL10406157 | 0.91 | TSHR (0.56) | TSHRUSP2TDP1HTTMAPT | |
| Propylene Glycol SCHEMBL8642766 | 0.89 | USP2 (0.62) | TSHRUSP2TDP1HTTMAPT | |
| Butoxyethanol SCHEMBL5926145 | 0.89 | TSHR (0.74) | TSHRUSP2TDP1HTTMAPT | |
| Propylene Glycol SCHEMBL7873540 | 0.89 | TSHR (0.54) | TSHRUSP2TDP1HTTMAPT | |
| Propylene Glycol SCHEMBL8641201 | 0.89 | USP2 (0.62) | TSHRUSP2TDP1HTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10093753-B2 | Syrup polymer compositions and adhesives therefrom | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2018-10-09 | — | — | US | disclosed |
| US-20170362348-A1 | SYRUP POLYMER COMPOSITIONS AND ADHESIVES THEREFROM | 3M INNOVATIVE PROPERTIES COMPANY | 2017-12-21 | — | — | US | disclosed |
| EP-3227347-A1 | SYRUP POLYMER COMPOSITIONS AND ADHESIVES THEREFROM | 3M Innovative Properties Company (US) | 2017-10-11 | — | — | EP | disclosed |
| WO-2016089805-A1 | SYRUP POLYMER COMPOSITIONS AND ADHESIVES THEREFROM | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2016-06-09 | — | — | WO | disclosed |
| US-8507612-B2 | Aziridine crosslinking agents for acrylic adhesives | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2013-08-13 | — | — | US | disclosed |
| US-8420214-B2 | Acrylic pressure-sensitive adhesives with aziridine crosslinking agents | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2013-04-16 | — | — | US | disclosed |
| EP-2406338-B1 | AZIRIDINE CROSSLINKING AGENTS FOR ACRYLIC ADHESIVES | 3M INNOVATIVE PROPERTIES CO (US) | 2012-11-28 | — | — | EP | disclosed |
| EP-1877510-B1 | WET AND DRY STICK ADHESIVE, ARTICLES, AND METHOD | 3M INNOVATIVE PROPERTIES CO (US) | 2012-08-15 | — | — | EP | disclosed |
| EP-2291478-B1 | ACRYLIC PRESSURE-SENSITIVE ADHESIVES WITH AZIRIDINE CROSSLINKING AGENTS | 3M INNOVATIVE PROPERTIES CO (US) | 2012-08-01 | — | — | EP | disclosed |
| EP-2406338-A1 | AZIRIDINE CROSSLINKING AGENTS FOR ACRYLIC ADHESIVES | 3M Innovative Properties Company (US) | 2012-01-18 | — | — | EP | disclosed |
| US-20110076493-A1 | Acrylic Pressure-Sensitive Adhesives with Aziridine Crosslinking Agents | 3M INNOVATIVE PROPERTIES COMPANY | 2011-03-31 | — | — | US | disclosed |
| EP-2291478-A1 | ACRYLIC PRESSURE-SENSITIVE ADHESIVES WITH AZIRIDINE CROSSLINKING AGENTS | 3M Innovative Properties Company (US) | 2011-03-09 | — | — | EP | disclosed |
| WO-2010104645-A1 | AZIRIDINE CROSSLINKING AGENTS FOR ACRYLIC ADHESIVES | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2010-09-16 | — | — | WO | disclosed |
| US-20100227969-A1 | AZIRIDINE CROSSLINKING AGENTS FOR ACRYLIC ADHESIVES | 3M INNOVATIVE PROPERTIES COMPANY | 2010-09-09 | — | — | US | disclosed |
| WO-2009152126-A1 | ACRYLIC PRESSURE-SENSITIVE ADHESIVES WITH AZIRIDINE CROSSLINKING AGENTS | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2009-12-17 | — | — | WO | disclosed |
| US-7442438-B2 | pressure sensitive layer disposed on the reinforced tape; maintains pressure sensitive adhesive performance properties to a range of substrates having both wet and dry surfaces | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2008-10-28 | — | — | US | disclosed |
| EP-1877510-A1 | WET AND DRY STICK ADHESIVE, ARTICLES, AND METHODS | 3M Innovative Properties Company (US) | 2008-01-16 | — | — | EP | disclosed |
| WO-2006119505-A1 | WET AND DRY STICK ADHESIVE, ARTICLES, AND METHODS | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2006-11-09 | — | — | WO | disclosed |
| US-20060251893-A1 | pressure sensitive layer disposed on the reinforced tape; maintains pressure sensitive adhesive performance properties to a range of substrates having both wet and dry surfaces | 3M INNOVATIVE PROPERTIES COMPANY | 2006-11-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100227969-A1 | AZIRIDINE CROSSLINKING AGENTS FOR ACRYLIC ADHESIVES | AAAS, ADGRF1, CDH1 | TSHR 4515/4885USP2 1372/4885TDP1 2266/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.