Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.49 |
| ▸ | KIF11 | P52732 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 2/20 | 0.47 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | PAK4 | O96013 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | LTK | P29376 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.47 |
| ▸ | CLK2 | P49760 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4960988 | 0.88 | CHEK1 (0.47) | CHEK1KIF11AURKADAPK3JAK2 | |
| SCHEMBL4960647 | 0.79 | MET (0.42) | CHEK1AURKAPARP1MEN1KMT2A | |
| SCHEMBL2628367 | 0.79 | ACHE (0.56) | CHEK1KIF11AURKAGSK3AGSK3B | |
| SCHEMBL21376875 | 0.77 | KIF11 (0.62) | KIF11MEN1KMT2AMAPTKDM4E | |
| SCHEMBL13010630 | 0.76 | KIF11 (0.79) | KIF11MEN1KMT2AMAPTKDM4E | |
| SCHEMBL31549973 | 0.76 | KIF11 (0.79) | KIF11MEN1KMT2AMAPTKDM4E | |
| SCHEMBL4958620 | 0.76 | CHEK1 (0.50) | CHEK1AURKAPARP1MEN1KMT2A | |
| SCHEMBL4959114 | 0.76 | BRD4 (0.43) | CHEK1AURKAALKPARP1MEN1 | |
| SCHEMBL4961015 | 0.76 | CHEK1 (0.53) | CHEK1AURKAPARP1MEN1KMT2A | |
| SCHEMBL13598899 | 0.76 | CHEK1 (0.53) | CHEK1AURKAALKPARP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116063302-A | Preparation method of alpha-carboline and derivative thereof | 南昌大学 | 2023-05-05 | — | — | CN | disclosed |