Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | HTR1F | P30939 | 2/20 | 0.44 |
| ▸ | ELANE | P08246 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27559710 | 0.84 | KMT2A (0.68) | SMN1; SMN2KMT2AHTTTDP1MAPT | |
| Iodide SCHEMBL30309840 | 0.83 | KMT2A (0.51) | KMT2ASSTR4L3MBTL1HTR1F | |
| SCHEMBL31538836 | 0.83 | ELANE (0.55) | SMN1; SMN2KMT2AHTTTDP1SSTR4 | |
| Iodide SCHEMBL31003069 | 0.81 | KMT2A (0.40) | SMN1; SMN2KMT2AHTTTDP1MAPT | |
| SCHEMBL4774121 | 0.80 | KMT2A (0.75) | SMN1; SMN2KMT2AHTTTDP1MAPT | |
| SCHEMBL2535788 | 0.80 | KMT2A (0.81) | SMN1; SMN2KMT2AHTTTDP1MAPT | |
| SCHEMBL15180794 | 0.80 | KMT2A (0.58) | SMN1; SMN2KMT2AHTTTDP1MAPT | |
| SCHEMBL4772584 | 0.79 | KMT2A (0.72) | SMN1; SMN2KMT2AHTTTDP1MAPT | |
| SCHEMBL9978095 | 0.79 | MAPT (0.63) | SMN1; SMN2KMT2AMAPTSSTR4ALDH1A1 | |
| Iodide SCHEMBL31003056 | 0.78 | HTR1F (0.43) | SMN1; SMN2KMT2ATDP1MAPTSSTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111447939-B | Method for preparing conjugate | 四川科伦博泰生物医药股份有限公司 | 2024-07-12 | — | — | CN | disclosed |
| CN-110090308-B | Method for preparing conjugate | 四川科伦博泰生物医药股份有限公司 | 2023-03-24 | — | — | CN | disclosed |