Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | FAAH | O00519 | 1/20 | 0.45 |
| ▸ | HTR1F | P30939 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6689211 | 0.85 | POLB (0.58) | KMT2APOLBL3MBTL1USP2 | |
| Iodide SCHEMBL30309833 | 0.83 | SMN1; SMN2 (0.53) | KMT2ASSTR4HTR1FL3MBTL1 | |
| SCHEMBL2535206 | 0.83 | POLB (0.63) | KMT2APOLBL3MBTL1USP2 | |
| SCHEMBL15224114 | 0.83 | POLB (0.68) | KMT2APOLBL3MBTL1USP2 | |
| SCHEMBL28099496 | 0.82 | POLB (0.41) | KMT2ASSTR4POLBFAAHUSP2 | |
| SCHEMBL10091153 | 0.82 | POLB (0.51) | KMT2APOLBL3MBTL1USP2 | |
| SCHEMBL27908646 | 0.81 | POLB (0.70) | KMT2APOLBL3MBTL1USP2 | |
| SCHEMBL31538836 | 0.81 | ELANE (0.55) | KMT2ASSTR4POLBL3MBTL1 | |
| SCHEMBL28688381 | 0.79 | POLB (0.51) | KMT2APOLBFAAHL3MBTL1USP2 | |
| Iodide SCHEMBL31003069 | 0.79 | KMT2A (0.40) | KMT2APOLBHTR1FL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111447939-B | Method for preparing conjugate | 四川科伦博泰生物医药股份有限公司 | 2024-07-12 | — | — | CN | disclosed |
| CN-110090308-B | Method for preparing conjugate | 四川科伦博泰生物医药股份有限公司 | 2023-03-24 | — | — | CN | disclosed |