Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1F | P30939 | 9/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.43 |
| ▸ | DRD5 | P21918 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | HTR1E | P28566 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.38 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL31003066 | 0.87 | HTR1F (0.39) | HTR1FCHRM5DRD5HTR1DHTR1E | |
| Iodide SCHEMBL31003069 | 0.79 | KMT2A (0.40) | HTR1FCHRM5DRD5HTR1DHTR1E | |
| SCHEMBL30309831 | 0.78 | TDP1 (0.37) | ALDH1A1TDP1L3MBTL1KMT2ASMN1; SMN2 | |
| Iodide SCHEMBL30309833 | 0.78 | SMN1; SMN2 (0.53) | HTR1FALDH1A1TDP1L3MBTL1KMT2A | |
| Iodide SCHEMBL30309840 | 0.76 | KMT2A (0.51) | HTR1FL3MBTL1KMT2ASSTR4 | |
| SCHEMBL21705623 | 0.75 | SLC6A4 (0.37) | HTR1FTDP1KMT2AHRH4SMN1; SMN2 | |
| SCHEMBL8230523 | 0.74 | NAMPT (0.43) | HTR1FCHRM5DRD5HTR1DHTR1E | |
| SCHEMBL31538836 | 0.69 | ELANE (0.55) | CHRM5ALDH1A1TDP1L3MBTL1KMT2A | |
| SCHEMBL13390919 | 0.69 | HTR1F (0.57) | HTR1FCHRM5DRD5HTR1DHTR1E | |
| SCHEMBL21984776 | 0.68 | HTR2A (0.37) | HTR1FCHRM5DRD5HTR1DHTR1E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111447939-B | Method for preparing conjugate | 四川科伦博泰生物医药股份有限公司 | 2024-07-12 | — | — | CN | disclosed |