Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK7 | P49862 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.37 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 5/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 5/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | ACACA | Q13085 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30311180 | 0.92 | KLK7 (0.41) | KLK7DPP4PRMT5TMEM97SIGMAR1 | |
| SCHEMBL22176306 | 0.88 | KLK7 (0.41) | KLK7DPP4PRMT5TMEM97SIGMAR1 | |
| SCHEMBL30311378 | 0.88 | KLK7 (0.41) | KLK7DPP4PRMT5TMEM97SIGMAR1 | |
| SCHEMBL30311421 | 0.87 | KLK7 (0.37) | KLK7DPP4PRMT5TMEM97SIGMAR1 | |
| SCHEMBL22164195 | 0.78 | TSHR (0.40) | TSHRMAPTNPSR1ALDH1A1LMNA | |
| SCHEMBL30311213 | 0.78 | AADAT (0.38) | KLK7PRMT5TMEM97SIGMAR1AADAT | |
| SCHEMBL221557 | 0.77 | TSHR (0.38) | TSHRMAPTNPSR1ALDH1A1LMNA | |
| SCHEMBL2737942 | 0.77 | PDE8B (0.40) | TSHRMAPTNPSR1ALDH1A1LMNA | |
| SCHEMBL15958257 | 0.77 | AADAT (0.48) | TMEM97SIGMAR1AADATNPSR1ALDH1A1 | |
| SCHEMBL30311147 | 0.77 | DPP4 (0.35) | DPP4PRMT5TSHRMAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230069963-A1 | PYRAZOLO[1,5-A]PYRIMIDINE MACROCYCLIC COMPOUND | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2023-03-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230069963-A1 | PYRAZOLO[1,5-A]PYRIMIDINE MACROCYCLIC COMPOUND | ZC3HAV1, ZC3HAV1L, IL5 | KLK7 1510/4885DPP4 57/4885PRMT5 356/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.