Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | PDE8B | O95263 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 6/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.31 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.31 |
| ▸ | CRHBP | P24387 | 1/20 | 0.31 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30311168 | 0.88 | ALDH1A1 (0.37) | ALDH1A1MEN1KMT2AL3MBTL1PDE8B | |
| SCHEMBL30311174 | 0.87 | PDE8B (0.38) | ALDH1A1MEN1KMT2AL3MBTL1PDE8B | |
| SCHEMBL30311159 | 0.81 | ALDH1A1 (0.36) | ALDH1A1MEN1KMT2AL3MBTL1PDE8B | |
| SCHEMBL30311175 | 0.81 | ACHE (0.34) | ALDH1A1MEN1KMT2AL3MBTL1PDE8B | |
| SCHEMBL21279655 | 0.80 | HPGD (0.39) | ALDH1A1MEN1KMT2AL3MBTL1PDE8B | |
| SCHEMBL2737908 | 0.80 | HPGD (0.39) | ALDH1A1MEN1KMT2AL3MBTL1PDE8B | |
| SCHEMBL2738201 | 0.79 | ALDH1A1 (0.35) | ALDH1A1MEN1KMT2AL3MBTL1NPSR1 | |
| SCHEMBL2737942 | 0.79 | PDE8B (0.40) | ALDH1A1MEN1KMT2AL3MBTL1PDE8B | |
| SCHEMBL2737945 | 0.77 | ABCB1 (0.41) | ALDH1A1MEN1KMT2AL3MBTL1PDE8B | |
| SCHEMBL2737944 | 0.77 | ABCB1 (0.41) | ALDH1A1MEN1KMT2AL3MBTL1PDE8B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230069963-A1 | PYRAZOLO[1,5-A]PYRIMIDINE MACROCYCLIC COMPOUND | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2023-03-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230069963-A1 | PYRAZOLO[1,5-A]PYRIMIDINE MACROCYCLIC COMPOUND | ZC3HAV1, ZC3HAV1L, IL5 | ALDH1A1 2801/4885MEN1 2874/4885KMT2A 3751/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.