Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | XDH | P47989 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | FUT7 | Q11130 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22026533 | 0.85 | KMT2A (0.50) | KDM4EALDH1A1CA12CA1CA2 | |
| Methyl Syringate SCHEMBL211747 | 0.84 | MEN1 (0.61) | KDM4EALDH1A1CA12CA1CA2 | |
| SCHEMBL31492679 | 0.82 | TUBB4A (0.53) | CYP3A4TSHR | |
| SCHEMBL31492675 | 0.82 | TUBB4A (0.53) | CYP3A4TSHR | |
| SCHEMBL30625037 | 0.81 | LMNA (0.52) | KDM4EALDH1A1MEN1KMT2ALMNA | |
| Veratric Acid Methyl Ester SCHEMBL2371276 | 0.80 | MAPT (0.70) | KDM4EALDH1A1CA12CA1CA2 | |
| SCHEMBL29728532 | 0.80 | TUBB4A (0.44) | KDM4EALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL29728529 | 0.79 | TUBB4A (0.39) | KDM4EALDH1A1MEN1KMT2ALMNA | |
| 3,4,5-Trimethoxybenzamide SCHEMBL29597349 | 0.79 | TSHR (0.54) | ALDH1A1MEN1KMT2ALMNATSHR | |
| Veratric Acid Methyl Ester SCHEMBL3661352 | 0.79 | MAPT (0.73) | KDM4EALDH1A1CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240368183-A1 | Macrocyclic Compounds Having ENT1 Inhibiting Activity | iTeos Belgium SA (BE) | 2024-11-07 | — | — | US | disclosed |
| EP-4413004-A1 | MACROCYCLIC COMPOUNDS HAVING ENT1 INHIBITING ACTIVITY | iTeos Belgium SA (BE) | 2024-08-14 | — | — | EP | disclosed |
| WO-2023059739-A1 | MACROCYCLIC COMPOUNDS HAVING ENT1 INHIBITING ACTIVITY | iTeos Belgium SA (US) | 2023-04-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240368183-A1 | Macrocyclic Compounds Having ENT1 Inhibiting Activity | ENTPD5, ENTPD1, ENTPD8 | KDM4E 3768/4885ALDH1A1 363/4885CA12 2350/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.