Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.54 |
| ▸ | AURKA | O14965 | 1/20 | 0.54 |
| ▸ | DRD3 | P35462 | 2/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.48 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | HTR3A | P46098 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | GHSR | Q92847 | 1/20 | 0.47 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7380121 | 1.00 | LMNA (0.57) | LMNACHRM1AURKADRD3OPRK1 | |
| SCHEMBL29216211 | 0.90 | LMNA (0.46) | LMNACHRM1AURKADRD3OPRK1 | |
| SCHEMBL10469878 | 0.87 | LMNA (0.43) | LMNACHRM1AURKADRD3OPRK1 | |
| SCHEMBL7377306 | 0.86 | GABRA1 (0.55) | LMNAOPRK1PDE4DCCNE2CCNE1 | |
| SCHEMBL10470303 | 0.86 | GABRA1 (0.41) | LMNACHRM1AURKAOPRK1GHSR | |
| SCHEMBL10471802 | 0.84 | GABRA1 (0.57) | LMNACHRM1AURKA | |
| SCHEMBL7955851 | 0.84 | CHRM1 (0.54) | LMNACHRM1AURKAOPRK1GHSR | |
| SCHEMBL10469968 | 0.84 | GABRA1 (0.41) | LMNACHRM1AURKAOPRK1PDE4D | |
| SCHEMBL11610206 | 0.84 | CHRM1 (0.51) | LMNACHRM1AURKADRD3OPRK1 | |
| SCHEMBL28551700 | 0.84 | CHRM1 (0.51) | LMNACHRM1AURKADRD3OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4405043-A1 | BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM | F. Hoffmann-La Roche AG (CH) | 2024-07-31 | — | — | EP | disclosed |
| WO-2023046817-A1 | BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM | F. HOFFMANN-LA ROCHE AG (CH) | 2023-03-30 | — | — | WO | disclosed |