SCHEMBL7377306

SCHEMBL7377306

NC1=Nc2ccc(Cl)cc2C(c2ccccc2Cl)=NC1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GABRA1 P14867 3/20 0.55
GABRA5 P31644 3/20 0.55
GABRA3 P34903 3/20 0.55
GABRA2 P47869 3/20 0.55
GABRG2 P18507 2/20 0.55
GABRB3 P28472 2/20 0.55
GABRB2 P47870 2/20 0.55
GABRP O00591 1/20 0.55
GABRD O14764 1/20 0.55
GABRB1 P18505 1/20 0.55
GABRA4 P48169 1/20 0.55
GABRE P78334 1/20 0.55
GABRA6 Q16445 1/20 0.55
GABRG1 Q8N1C3 1/20 0.55
GABRG3 Q99928 1/20 0.55
GABRQ Q9UN88 1/20 0.55
ALOX12 P18054 1/20 0.52
SMN1; SMN2 Q16637 1/20 0.52
TP53 P04637 2/20 0.49
HTR2A P28223 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10470364 0.89 GABRA1 (0.52) GABRA1GABRA5GABRA3GABRA2GABRG2
SCHEMBL10469874 0.87 GABRA1 (0.45) GABRA1GABRA5GABRA3GABRA2GABRG2
SCHEMBL30320290 0.86 LMNA (0.57) OPRK1PDE4DLMNACCNE2CCNE1
SCHEMBL10469968 0.86 GABRA1 (0.41) GABRA1GABRA5GABRA3GABRA2GABRG2
SCHEMBL10469769 0.86 GRM2 (0.43) GABRA1GABRA5GABRA3GABRA2GABRG2
SCHEMBL10469811 0.86 GABRA1 (0.41) GABRA1GABRA5GABRA3GABRA2GABRG2
SCHEMBL7380121 0.86 LMNA (0.57) OPRK1PDE4DLMNACCNE2CCNE1
SCHEMBL7370183 0.84 OPRK1 (0.54) GABRA1GABRA5GABRA3GABRA2GABRG2
SCHEMBL11534409 0.83 GABRA1 (0.52) GABRA1GABRA5GABRA3GABRA2GABRG2
Hydrochloric Acid SCHEMBL11654812 0.83 OPRK1 (0.53) GABRA1GABRA5GABRA3GABRA2GABRG2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4978753-A 7-phenylpyrimido[1,2-alpha][1,4]benzodiazepin-3(5H)-ones THE UPJOHN COMPANY (US) 1990-12-18 US claimed
EP-0801651-B1 HYDROXYMETHYLIMIDAZODIAZEPINES AND THEIR ESTERS HOFFMANN LA ROCHE (CH) 2001-07-11 EP disclosed
US-6174881-B1 USED AS ANXIOLYTIC AND/OR ANTICONVULSANT AND/OR MUSCLE RELAXANT AGENTS; SEDATIVES OR HYPNOSIS; WATER-SOLUBLE AMINE SALTS; FAST-ACTING HOFFMAN-LA ROCHE INC. 2001-01-16 US disclosed
CN-1168140-A Hydroxymethyl imidazodiazepine * and esters thereof HOFFMANN LA ROCHE (CH) 1997-12-17 CN disclosed
EP-0801651-A1 HYDROXYMETHYLIMIDAZODIAZEPINES AND THEIR ESTERS F. HOFFMANN-LA ROCHE AG (CH) 1997-10-22 EP disclosed
WO-1996020941-A1 HYDROXYMETHYLIMIDAZODIAZEPINES AND THEIR ESTERS F. HOFFMANN-LA ROCHE AG (CH) 1996-07-11 WO disclosed
US-4978753-A 7-phenylpyrimido[1,2-alpha][1,4]benzodiazepin-3(5H)-ones THE UPJOHN COMPANY (US) 1990-12-18 US disclosed