Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.37 |
| ▸ | USP1 | O94782 | 5/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.33 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25792027 | 1.00 | PTGS2 (0.37) | PTGS2USP1HSD11B1PTGS1CRHR1 | |
| SCHEMBL30320408 | 0.86 | USP1 (0.44) | PTGS2USP1PTGS1DGAT1 | |
| SCHEMBL25791872 | 0.86 | USP1 (0.44) | PTGS2USP1PTGS1DGAT1 | |
| SCHEMBL25247029 | 0.83 | USP1 (0.44) | PTGS2USP1HSD11B1PTGS1CRHR1 | |
| SCHEMBL25792053 | 0.83 | USP1 (0.39) | PTGS2USP1PTGS1DGAT1 | |
| SCHEMBL30320434 | 0.83 | USP1 (0.39) | PTGS2USP1PTGS1DGAT1 | |
| SCHEMBL25791868 | 0.81 | USP1 (0.46) | PTGS2USP1PTGS1DGAT1 | |
| SCHEMBL25252227 | 0.81 | PTGS2 (0.36) | PTGS2USP1HSD11B1PTGS1CRHR1 | |
| SCHEMBL25290034 | 0.80 | RXRA (0.34) | PTGS2USP1RXRADGAT1 | |
| SCHEMBL25344707 | 0.74 | USP1 (0.40) | PTGS2USP1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4161494-A1 | NITROGEN-CONTAINING FUSED BICYCLIC COMPOUNDS AND THEIR USE AS UBIQUITIN-SPECIFIC-PROCESSING PROTEASE 1 (USP1) INHIBITORS | KSQ Therapeutics, Inc. (US) | 2023-04-12 | — | — | EP | disclosed |