Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 11/20 | 0.54 |
| ▸ | MAPT | P10636 | 8/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | JMJD6 | Q6NYC1 | 3/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31629807 | 0.83 | ALDH1A1 (0.54) | KMT2AMAPTTSHRKDM4EALDH1A1 | |
| SCHEMBL27600721 | 0.80 | KMT2A (0.50) | KMT2AMAPTTSHRSMN1; SMN2HPGD | |
| SCHEMBL27690103 | 0.79 | KMT2A (0.60) | KMT2AMAPTTSHRSMN1; SMN2HPGD | |
| SCHEMBL25117691 | 0.69 | KMT2A (0.35) | KMT2ATSHRSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL2804720 | 0.69 | KMT2A (0.52) | KMT2AMAPTTSHRSMN1; SMN2KDM4E | |
| Phosphine SCHEMBL9591710 | 0.69 | LMNA (0.67) | KMT2AMAPTTSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL30532884 | 0.68 | LMNA (0.53) | KMT2AMAPTTSHRSMN1; SMN2HPGD | |
| SCHEMBL2829058 | 0.68 | LMNA (0.53) | KMT2AMAPTTSHRSMN1; SMN2HPGD | |
| SCHEMBL28690697 | 0.68 | TSHR (0.50) | KMT2AMAPTTSHRSMN1; SMN2HPGD | |
| SCHEMBL31396932 | 0.68 | LMNA (0.49) | KMT2AMAPTTSHRSMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4161494-A1 | NITROGEN-CONTAINING FUSED BICYCLIC COMPOUNDS AND THEIR USE AS UBIQUITIN-SPECIFIC-PROCESSING PROTEASE 1 (USP1) INHIBITORS | KSQ Therapeutics, Inc. (US) | 2023-04-12 | — | — | EP | disclosed |