Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 4/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL189015 | 1.00 | LMNA (0.47) | LMNATRPV4SMN1; SMN2NPC1MAPT | |
| SCHEMBL16904329 | 0.85 | CHRNB2 (0.40) | LMNATRPV4SMN1; SMN2NPC1CHRNB2 | |
| SCHEMBL3513772 | 0.80 | MEN1 (0.46) | LMNASMN1; SMN2CHRNB2CHRNA4DRD1 | |
| SCHEMBL30454073 | 0.80 | MEN1 (0.46) | LMNASMN1; SMN2CHRNB2CHRNA4DRD1 | |
| SCHEMBL29781487 | 0.78 | TRPV4 (0.42) | LMNATRPV4SMN1; SMN2NPC1MAPT | |
| SCHEMBL21801532 | 0.78 | TRPV4 (0.42) | LMNATRPV4SMN1; SMN2NPC1MAPT | |
| SCHEMBL14862285 | 0.77 | CHRNB2 (0.43) | LMNASMN1; SMN2NPC1MAPTRAB9A | |
| SCHEMBL1536481 | 0.77 | LMNA (0.45) | LMNATRPV4SMN1; SMN2NPC1MAPT | |
| SCHEMBL16586557 | 0.76 | LMNA (0.43) | LMNASMN1; SMN2NPC1MAPTRAB9A | |
| SCHEMBL189173 | 0.76 | TRPV4 (0.41) | LMNATRPV4SMN1; SMN2NPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117157291-A | Heterocyclic derivatives as P2X7 receptor antagonists | 布雷耶疗法有限公司 | 2023-12-01 | — | — | CN | disclosed |
| WO-2023122093-A1 | REV-ERB AGONISTS FOR TH17-MEDIATED INFLAMMATORY DISORDERS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2023-06-29 | — | — | WO | disclosed |
| EP-4161494-A1 | NITROGEN-CONTAINING FUSED BICYCLIC COMPOUNDS AND THEIR USE AS UBIQUITIN-SPECIFIC-PROCESSING PROTEASE 1 (USP1) INHIBITORS | KSQ Therapeutics, Inc. (US) | 2023-04-12 | — | — | EP | disclosed |