Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | FABP4 | P15090 | 2/20 | 0.42 |
| ▸ | RORC | P51449 | 6/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TFPI2 | P48307 | 1/20 | 0.39 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.39 |
| ▸ | ALKBH1 | Q13686 | 2/20 | 0.38 |
| ▸ | SCN2B | O60939 | 1/20 | 0.38 |
| ▸ | SCN1A | P35498 | 1/20 | 0.38 |
| ▸ | SCN1B | Q07699 | 1/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28419807 | 0.78 | SLC6A2 (0.45) | MEN1KMT2AKDM4E | |
| SCHEMBL6840222 | 0.78 | RORC (0.60) | MEN1KMT2AKDM4ERORCCYP2C9 | |
| SCHEMBL24930901 | 0.75 | ALDH1A1 (0.49) | MEN1KMT2AKDM4ERORC | |
| SCHEMBL31097642 | 0.74 | HTT (0.50) | KDM4ERORCCYP2C9SLC22A12ALKBH1 | |
| SCHEMBL25372637 | 0.74 | HTT (0.50) | KDM4ERORCCYP2C9SLC22A12ALKBH1 | |
| SCHEMBL3678410 | 0.70 | HTR3A (0.51) | KDM4ERORCCYP2C9SLC22A12 | |
| SCHEMBL17373146 | 0.70 | POLB (0.50) | MEN1KMT2AKDM4E | |
| SCHEMBL1881442 | 0.69 | NR4A2 (0.51) | MEN1KMT2AKDM4EFABP4RORC | |
| SCHEMBL6840201 | 0.68 | SCN2B (0.68) | KDM4ERORCCYP2C9SLC22A12SCN2B | |
| SCHEMBL19180068 | 0.67 | NR4A2 (0.50) | MEN1KMT2AKDM4EFABP4RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11958850-B2 | Heteroaryl compounds for kinase inhibition | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2024-04-16 | — | — | US | disclosed |
| US-20230102829-A1 | Heteroaryl Compounds For Kinase Inhibition | ARIAD PHARMACEUTICALS, INC. | 2023-03-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11958850-B2 | Heteroaryl compounds for kinase inhibition | ERBB2, EGFR, ERBB3 | MEN1 3224/4885KMT2A 1587/4885KDM4E 3491/4885 |
| US-20230102829-A1 | Heteroaryl Compounds For Kinase Inhibition | ERBB2, EGFR, ERBB3 | MEN1 3224/4885KMT2A 1587/4885KDM4E 3491/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.