Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.41 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.41 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.41 |
| ▸ | STS | P08842 | 4/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.39 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.39 |
| ▸ | TACR3 | P29371 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16651835 | 0.83 | STS (0.42) | USP30STSGPR119JAK2JAK1 | |
| SCHEMBL16662458 | 0.82 | USP30 (0.41) | USP30POLBMEN1KMT2AGPR119 | |
| SCHEMBL6179731 | 0.81 | MEN1 (0.61) | POLBMEN1KMT2APROKR1STS | |
| SCHEMBL20757641 | 0.80 | PDE4B (0.46) | USP30POLBMEN1KMT2APROKR1 | |
| SCHEMBL30094557 | 0.80 | PDE4B (0.46) | USP30POLBMEN1KMT2APROKR1 | |
| SCHEMBL3019433 | 0.79 | MEN1 (0.58) | MEN1KMT2ASTSABL1RIN1 | |
| SCHEMBL30187837 | 0.79 | SLC5A1 (0.46) | POLBSTSGPR119ANO1 | |
| SCHEMBL19740830 | 0.79 | SLC5A1 (0.46) | POLBSTSGPR119ANO1 | |
| SCHEMBL30324497 | 0.77 | RORC (0.42) | USP30POLBGPR119JAK2JAK1 | |
| SCHEMBL2882463 | 0.76 | KDM4E (0.51) | USP30MEN1KMT2ASTSGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4164654-A1 | RIPK1 INHIBITORS AND METHODS OF USE | Merck Sharp & Dohme LLC (US) | 2023-04-19 | — | — | EP | disclosed |