Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26105375 | 0.85 | RORC (0.43) | RORCPOLBJAK2JAK1PDE4B | |
| SCHEMBL30324512 | 0.84 | GPR119 (0.46) | RORCJAK2JAK1GPR119 | |
| SCHEMBL24111414 | 0.84 | GPR119 (0.46) | RORCJAK2JAK1GPR119 | |
| SCHEMBL30094557 | 0.79 | PDE4B (0.46) | POLBPDE4BANO1GPR119USP30 | |
| SCHEMBL20757641 | 0.79 | PDE4B (0.46) | POLBPDE4BANO1GPR119USP30 | |
| SCHEMBL17729471 | 0.78 | MAPT (0.52) | RORCGPR119USP30TACR1 | |
| SCHEMBL23802575 | 0.77 | GPR119 (0.49) | RORCPOLBGPR119USP30 | |
| SCHEMBL30324594 | 0.77 | USP30 (0.43) | POLBJAK2JAK1ANO1GPR119 | |
| SCHEMBL17541957 | 0.76 | RORC (0.49) | RORCUSP30 | |
| SCHEMBL20570727 | 0.76 | RORC (0.49) | RORCPDE4BGPR119USP30TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4164654-A1 | RIPK1 INHIBITORS AND METHODS OF USE | Merck Sharp & Dohme LLC (US) | 2023-04-19 | — | — | EP | disclosed |