Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 17/20 | 0.63 |
| ▸ | OPRM1 | P35372 | 16/20 | 0.63 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2379087 | 0.99 | OPRL1 (0.62) | OPRL1OPRM1OPRK1CYP2C9 | |
| SCHEMBL2379624 | 0.92 | OPRL1 (0.54) | OPRL1OPRM1ALDH1A1CYP2C19 | |
| Hydrochloric Acid SCHEMBL302160 | 0.91 | OPRL1 (0.53) | OPRL1OPRM1ALDH1A1CYP2C19 | |
| SCHEMBL2378997 | 0.88 | OPRL1 (0.51) | OPRL1OPRM1ALDH1A1CYP2C19 | |
| Hydrochloric Acid SCHEMBL303067 | 0.87 | OPRL1 (0.52) | OPRL1OPRM1ALDH1A1CYP2C19 | |
| SCHEMBL2379621 | 0.86 | OPRM1 (0.60) | OPRL1OPRM1CYP2C9LMNACYP2D6 | |
| Hydrochloric Acid SCHEMBL302718 | 0.85 | OPRL1 (0.61) | OPRL1OPRM1CYP2C9LMNACYP2D6 | |
| SCHEMBL2379697 | 0.85 | OPRM1 (0.56) | OPRL1OPRM1ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL302064 | 0.84 | OPRL1 (0.57) | OPRL1OPRM1ALDH1A1 | |
| SCHEMBL2379397 | 0.83 | OPRL1 (0.58) | OPRL1OPRM1LMNACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4852536-B2 | — | — | 2012-01-11 | — | — | JP | claimed |
| US-8017630-B2 | Cyclohexylacetic acid compounds | GRUENENTHAL GMBH (DE) | 2011-09-13 | — | — | US | claimed |
| EP-1751093-B1 | SUBSTITUTED CYCLOHEXYLACETIC ACID DERIVATIVES | GRUENENTHAL GMBH (DE) | 2010-10-06 | — | — | EP | claimed |
| US-20070129347-A1 | Cyclohexylacetic acid compounds | GRUENENTHAL GMBH (DE) | 2007-06-07 | — | — | US | claimed |
| EP-1751093-A1 | SUBSTITUTED CYCLOHEXYLACETIC ACID DERIVATIVES | Grünenthal GmbH (DE) | 2007-02-14 | — | — | EP | claimed |
| WO-2005110976-A1 | SUBSTITUTED CYCLOHEXYLACETIC ACID DERIVATIVES | Grünenthal GmbH (DE) | 2005-11-24 | — | — | WO | claimed |
| US-8017630-B2 | Cyclohexylacetic acid compounds | GRUENENTHAL GMBH (DE) | 2011-09-13 | — | — | US | disclosed |
| EP-1751093-B1 | SUBSTITUTED CYCLOHEXYLACETIC ACID DERIVATIVES | GRUENENTHAL GMBH (DE) | 2010-10-06 | — | — | EP | disclosed |
| US-20070129347-A1 | Cyclohexylacetic acid compounds | GRUENENTHAL GMBH (DE) | 2007-06-07 | — | — | US | disclosed |
| EP-1751093-A1 | SUBSTITUTED CYCLOHEXYLACETIC ACID DERIVATIVES | Grünenthal GmbH (DE) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005110976-A1 | SUBSTITUTED CYCLOHEXYLACETIC ACID DERIVATIVES | Grünenthal GmbH (DE) | 2005-11-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070129347-A1 | Cyclohexylacetic acid compounds | ACACA, HCAR2, PCCA | OPRL1 2478/4885OPRM1 3702/4885OPRK1 1430/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.