Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | TAS2R8 | Q9NYW2 | 15/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31412439 | 0.90 | HDAC3 (0.46) | ALDH1A1MAPTTAS2R8SMN1; SMN2HPGD | |
| SCHEMBL30325997 | 0.86 | HDAC3 (0.48) | ALDH1A1MAPTTAS2R8HPGDRAB9A | |
| SCHEMBL30389019 | 0.81 | ALDH1A1 (0.45) | ALDH1A1MAPTTAS2R8SMN1; SMN2HPGD | |
| SCHEMBL28988108 | 0.77 | ALDH1A1 (0.36) | ALDH1A1MAPTSMN1; SMN2MAPK1 | |
| SCHEMBL10646837 | 0.71 | MAPT (0.46) | ALDH1A1MAPTSMN1; SMN2HPGDRAB9A | |
| SCHEMBL28988144 | 0.68 | HDAC3 (0.48) | ALDH1A1MAPTTAS2R8HPGDRAB9A | |
| SCHEMBL30326080 | 0.68 | HDAC3 (0.48) | ALDH1A1MAPTTAS2R8HPGDRAB9A | |
| SCHEMBL30389409 | 0.68 | LMNA (0.35) | ALDH1A1MAPTTAS2R8RAB9AKMT2A | |
| SCHEMBL16660697 | 0.68 | MAPT (0.41) | ALDH1A1MAPTSMN1; SMN2HPGDRAB9A | |
| SCHEMBL25260370 | 0.66 | ALDH1A1 (0.45) | ALDH1A1MAPTTAS2R8SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4164634-A1 | PLASMA KALLIKREIN INHIBITORS | Merck Sharp & Dohme LLC (US) | 2023-04-19 | — | — | EP | disclosed |