Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.43 |
| ▸ | SCD | O00767 | 4/20 | 0.42 |
| ▸ | SCD5 | Q86SK9 | 4/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ITK | Q08881 | 1/20 | 0.40 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TCF4 | P15884 | 1/20 | 0.39 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29483796 | 0.83 | HDAC3 (0.55) | ALDH1A1SMN1; SMN2MAPTHDAC3HDAC8 | |
| SCHEMBL25308051 | 0.79 | SCD (0.43) | ALDH1A1SMN1; SMN2MAPTNPSR1HDAC3 | |
| SCHEMBL18795013 | 0.73 | GRM2 (0.42) | ALDH1A1SMN1; SMN2MAPTLMNAKDM4E | |
| SCHEMBL4516147 | 0.72 | LMNA (0.70) | ALDH1A1SMN1; SMN2MAPTHDAC3HDAC8 | |
| SCHEMBL29546318 | 0.66 | SIRT6 (0.44) | ALDH1A1SMN1; SMN2KMT2AHPGD | |
| SCHEMBL17008544 | 0.66 | SIRT6 (0.44) | ALDH1A1SMN1; SMN2KMT2AHPGD | |
| SCHEMBL30389019 | 0.66 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL30326147 | 0.66 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL3323704 | 0.66 | MAP3K5 (0.51) | ALDH1A1MAPT | |
| SCHEMBL18593075 | 0.65 | HDAC3 (0.64) | ALDH1A1SMN1; SMN2MAPTNPSR1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230416227-A1 | PLASMA KALLIKREIN INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2023-12-28 | — | — | US | disclosed |
| EP-4210694-A1 | PLASMA KALLIKREIN INHIBITORS | Merck Sharp & Dohme LLC (US) | 2023-07-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230416227-A1 | PLASMA KALLIKREIN INHIBITORS | KLKB1, SERPINE1, KLK5 | ALDH1A1 1701/4885SMN1; SMN2 4669/4885MAPT 781/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.