Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 1/20 | 0.48 |
| ▸ | ACACB | O00763 | 5/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 2/20 | 0.40 |
| ▸ | TNKS | O95271 | 1/20 | 0.40 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30328168 | 0.90 | CYP11B2 (0.48) | CYP11B2ACACBRETHDAC2HDAC1 | |
| SCHEMBL30328284 | 0.88 | CYP11B2 (0.48) | CYP11B2ACACBRETHDAC2HDAC1 | |
| SCHEMBL30327620 | 0.84 | ACACB (0.42) | CYP11B2ACACBHDAC2HDAC1OPRM1 | |
| SCHEMBL30327926 | 0.82 | ACACB (0.46) | CYP11B2ACACBRETHDAC2HDAC1 | |
| SCHEMBL30329263 | 0.82 | CYP11B2 (0.48) | CYP11B2ACACBRETHDAC2HDAC1 | |
| SCHEMBL30328552 | 0.82 | CYP11B2 (0.50) | CYP11B2ACACBRETHDAC2HDAC1 | |
| SCHEMBL30327742 | 0.81 | CYP11B2 (0.49) | CYP11B2ACACBRETGPR119CYP2C19 | |
| SCHEMBL30328063 | 0.80 | CYP3A4 (0.47) | CYP11B2ACACBRETGPR119JAK2 | |
| SCHEMBL30327871 | 0.80 | CYP11B2 (0.48) | CYP11B2ACACBRETHDAC2HDAC1 | |
| SCHEMBL30328379 | 0.80 | SMARCA2 (0.48) | CYP11B2ACACBRETHDAC2HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4415706-A1 | SMALL MOLECULE MODULATORS OF GLUCOCEREBROSIDASE ACTIVITY AND USES THEREOF | Vanqua Bio, Inc. (US) | 2024-08-21 | — | — | EP | disclosed |
| WO-2023064343-A1 | SMALL MOLECULE MODULATORS OF GLUCOCEREBROSIDASE ACTIVITY AND USES THEREOF | VANQUA BIO, INC. (US) | 2023-04-20 | — | — | WO | disclosed |