Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CXCR3 | P49682 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2188016 | 0.90 | KDM4E (0.43) | LMNAHTTKDM4EALDH1A1NPC1 | |
| SCHEMBL3376222 | 0.88 | MAPT (0.45) | LMNAKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL302225 | 0.80 | LMNA (0.60) | LMNAHTTKDM4EALDH1A1MEN1 | |
| SCHEMBL3377457 | 0.78 | MAPT (0.40) | LMNAKDM4EALDH1A1NPC1MEN1 | |
| SCHEMBL2186493 | 0.78 | ALDH1A1 (0.62) | LMNAHTTKDM4EALDH1A1HPGD | |
| SCHEMBL3379160 | 0.78 | LMNA (0.49) | LMNAHTTNPSR1KDM4EALDH1A1 | |
| SCHEMBL302155 | 0.78 | MEN1 (0.47) | KDM4EALDH1A1NPC1MEN1KMT2A | |
| SCHEMBL301863 | 0.78 | MEN1 (0.49) | KDM4EALDH1A1NPC1MEN1KMT2A | |
| SCHEMBL2185822 | 0.77 | RAB9A (0.59) | LMNAHTTKDM4EALDH1A1NPC1 | |
| SCHEMBL2188175 | 0.77 | NPC1 (0.38) | LMNAHTTKDM4EALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2012500836-A | — | — | 2012-01-12 | — | — | JP | claimed |
| EP-2342177-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | Xention Limited (GB) | 2011-07-13 | — | — | EP | claimed |
| WO-2010023448-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | XENTION LIMITED (GB) | 2010-03-04 | — | — | WO | claimed |