Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.40 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.40 |
| ▸ | USP7 | Q93009 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29017213 | 1.00 | GLS (0.43) | GLSMAPK1CCNA2CDK2CCNA1 | |
| SCHEMBL29017123 | 0.89 | CCNA2 (0.52) | GLSMAPK1CCNA2CDK2CCNA1 | |
| SCHEMBL29017136 | 0.89 | CCNA2 (0.52) | GLSMAPK1CCNA2CDK2CCNA1 | |
| SCHEMBL30336987 | 0.89 | CCNA2 (0.52) | GLSMAPK1CCNA2CDK2CCNA1 | |
| SCHEMBL29017158 | 0.74 | GLS (0.62) | GLS | |
| SCHEMBL29017138 | 0.74 | GLS (0.62) | GLS | |
| SCHEMBL30336995 | 0.74 | GLS (0.62) | GLS | |
| SCHEMBL29017167 | 0.73 | GLS (0.53) | GLS | |
| SCHEMBL29017180 | 0.72 | GLS (0.61) | GLS | |
| SCHEMBL29017177 | 0.72 | GLS (0.61) | GLS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115594683-A | Glutaminase GLS1 inhibitor and preparation method and application thereof | 杭州禹胜医药科技有限公司（CN） | 2023-01-13 | — | — | CN | disclosed |