SCHEMBL30338447

SCHEMBL30338447

NCc1ccc(CNC2CCCc3cccnc32)cc1Cc1ccccn1

nearest known ligand 0.52

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
CXCR4 P61073 17/20 0.52
HDAC1 Q13547 2/20 0.52
HDAC6 Q9UBN7 2/20 0.52
CYP3A4 P08684 3/20 0.38
CYP2D6 P10635 3/20 0.38
PRMT5 O14744 1/20 0.38
CHRM3 P20309 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5575207 0.92 CXCR4 (0.50) CXCR4HDAC1HDAC6CYP3A4CYP2D6
SCHEMBL31059309 0.82 CXCR4 (0.61) CXCR4
SCHEMBL7104696 0.82 CXCR4 (0.61) CXCR4
SCHEMBL23780245 0.80 HDAC1 (0.47) CXCR4HDAC1HDAC6CYP3A4CYP2D6
SCHEMBL21055028 0.80 HDAC1 (0.68) CXCR4HDAC1HDAC6CYP3A4CYP2D6
SCHEMBL29823139 0.79 HDAC1 (0.62) CXCR4HDAC1HDAC6CYP3A4CYP2D6
SCHEMBL1882612 0.79 HDAC1 (0.62) CXCR4HDAC1HDAC6CYP3A4CYP2D6
Bromide SCHEMBL4543315 0.79 HDAC1 (0.61) CXCR4HDAC1HDAC6CYP3A4CYP2D6
SCHEMBL13909820 0.79 HDAC1 (0.76) CXCR4HDAC1HDAC6CYP3A4CYP2D6
SCHEMBL5575215 0.78 HDAC1 (0.65) CXCR4HDAC1HDAC6CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115997009-A Methods and compositions for in vivo transduction of hematopoietic stem and progenitor cells 美真达治疗公司 2023-04-21 CN disclosed