SCHEMBL23780245

SCHEMBL23780245

NCc1ccc(CNC2CCCc3cccnc32)cc1CCNCc1ccc2ccccc2c1

nearest known ligand 0.47

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 2/20 0.47
HDAC6 Q9UBN7 2/20 0.47
CXCR4 P61073 11/20 0.42
MC5R P33032 3/20 0.39
MC4R P32245 2/20 0.39
MC3R P41968 2/20 0.38
SLC40A1 Q9NP59 1/20 0.38
MC1R Q01726 1/20 0.37
CA12 O43570 1/20 0.36
CA1 P00915 1/20 0.36
CA2 P00918 1/20 0.36
CA4 P22748 1/20 0.36
CYP3A4 P08684 1/20 0.35
CYP2D6 P10635 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30338447 0.80 CXCR4 (0.52) HDAC1HDAC6CXCR4CYP3A4CYP2D6
SCHEMBL7104696 0.76 CXCR4 (0.61) CXCR4
SCHEMBL31059309 0.76 CXCR4 (0.61) CXCR4
SCHEMBL21055028 0.76 HDAC1 (0.68) HDAC1HDAC6CXCR4CYP3A4CYP2D6
SCHEMBL13909820 0.74 HDAC1 (0.76) HDAC1HDAC6CXCR4CYP3A4CYP2D6
SCHEMBL13909521 0.74 HDAC1 (0.56) HDAC1HDAC6CXCR4CYP3A4CYP2D6
SCHEMBL5575215 0.74 HDAC1 (0.65) HDAC1HDAC6CXCR4CYP3A4CYP2D6
SCHEMBL5575207 0.73 CXCR4 (0.50) HDAC1HDAC6CXCR4CYP3A4CYP2D6
SCHEMBL4562865 0.72 HDAC1 (0.69) HDAC1HDAC6CXCR4CYP3A4CYP2D6
SCHEMBL4887341 0.72 HDAC1 (0.69) HDAC1HDAC6CXCR4CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3874027-A2 METHODS FOR HEMATOPOIETIC STEM AND PROGENITOR CELL TRANSPLANT THERAPY Magenta Therapeutics, Inc. (US) 2021-09-08 EP disclosed