Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | MAOB | P27338 | 3/20 | 0.56 |
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | CA9 | Q16790 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.53 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.53 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.52 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.52 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.52 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21348251 | 0.97 | HRH3 (0.66) | HRH3SMN1; SMN2TDP1MAOBCA12 | |
| SCHEMBL3044721 | 0.84 | MAOB (0.64) | HRH3SMN1; SMN2MAOBNPC1TP53 | |
| SCHEMBL3038005 | 0.84 | HRH3 (0.77) | HRH3NPC1TP53RAB9A | |
| SCHEMBL28255630 | 0.83 | HRH3 (0.66) | HRH3SMN1; SMN2MAOBNPC1TP53 | |
| SCHEMBL31484892 | 0.82 | HRH3 (0.78) | HRH3SMN1; SMN2NPC1TP53RAB9A | |
| SCHEMBL21347483 | 0.82 | HRH3 (0.68) | HRH3SMN1; SMN2MAOBNPC1TP53 | |
| SCHEMBL6057451 | 0.81 | HRH3 (0.82) | HRH3 | |
| SCHEMBL7811609 | 0.81 | NPC1 (0.78) | HRH3SMN1; SMN2NPC1TP53RAB9A | |
| SCHEMBL21348314 | 0.81 | HRH3 (0.70) | HRH3SMN1; SMN2NPC1TP53RAB9A | |
| SCHEMBL21347499 | 0.81 | HRH3 (0.66) | HRH3SMN1; SMN2MAOBALDH1A1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108912029-A | Nitrogen-containing heterocycle amide derivatives and application thereof | 广东东阳光药业有限公司 | 2018-11-30 | — | — | CN | disclosed |
| US-20100216762-A1 | Agonists and Antagonists of the S1P5 Receptor, and Methods of Use Thereof | ABBOTT LABORATORIES (US) | 2010-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216762-A1 | Agonists and Antagonists of the S1P5 Receptor, and Methods of Use Thereof | S1PR5, LPAR5, S1PR1 | HRH3 469/4885SMN1; SMN2 148/4885TDP1 1587/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.