SCHEMBL3034487

SCHEMBL3034487

O=C(O)c1ccc(CN2C(=O)C=CC2=O)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS1 P23219 1/20 1.00
PTGS2 P35354 1/20 1.00
MGLL Q99685 4/20 0.69
FAAH O00519 2/20 0.69
GSK3A P49840 2/20 0.62
GSK3B P49841 2/20 0.62
ENPP2 Q13822 1/20 0.55
MEN1 O00255 4/20 0.54
KMT2A Q03164 4/20 0.54
ALDH1A1 P00352 3/20 0.54
POLB P06746 3/20 0.54
GAA P10253 2/20 0.54
MAPT P10636 2/20 0.54
THRB P10828 2/20 0.54
RECQL P46063 2/20 0.54
TDP1 Q9NUW8 2/20 0.54
L3MBTL1 Q9Y468 2/20 0.54
HTT P42858 1/20 0.54
DDAH1 O94760 1/20 0.53
KDM4E B2RXH2 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL146412 0.83 MGLL (1.00) PTGS1PTGS2MGLLFAAHGSK3A
SCHEMBL1885239 0.83 PTGS1 (0.71) PTGS1PTGS2MGLLFAAHGSK3A
SCHEMBL14207256 0.79 PTGS1 (0.66) PTGS1PTGS2ENPP2MEN1KMT2A
SCHEMBL10974744 0.79 GSK3A (0.67) PTGS1PTGS2MGLLFAAHGSK3A
SCHEMBL24939709 0.78 PTGS1 (0.64) PTGS1PTGS2ENPP2MEN1KMT2A
SCHEMBL4804503 0.78 MGLL (0.78) PTGS1PTGS2MGLLFAAHGSK3A
SCHEMBL8950019 0.77 MGLL (0.86) PTGS1PTGS2MGLLFAAHGSK3A
SCHEMBL21215698 0.77 MGLL (0.86) PTGS1PTGS2MGLLFAAHGSK3A
SCHEMBL25435490 0.77 MGLL (1.00) PTGS1PTGS2MGLLFAAHGSK3A
SCHEMBL207740 0.77 MGLL (1.00) PTGS1PTGS2MGLLFAAHGSK3A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0310413-B1 Immobilized antibodies JAPAN CHEM RES (JP) 1994-03-16 EP claimed
EP-0336856-B1 WITH MALEIMIDE GROUPS FUNCTIONALIZED AROMATIC POLYAMIDEIMIDES, PROCESS FOR THEIR PREPARATION AND THEIR USE FOR PREPARING CROSS-LINKED POLYMERS CIBA-GEIGY AG (CH) 1993-03-03 EP claimed
US-4927900-A Aromatic polyamidoimides having maleimido end groups RHONE-POULENC CHIMIE (FR) 1990-05-22 US claimed
EP-0310413-A2 Immobilized antibodies NIHON CHEMICAL RESEARCH KABUSHIKI KAISHA also known as JCR PHARMACEUTICALS CO., LTD (JP) 1989-04-05 EP claimed
US-20250367317-A1 COMPOUND HAVING AFFINITY SUBSTANCE TO ANTIBODY AND BIOORTHOGONAL FUNCTIONAL GROUP, OR SALT THEREOF AJINOMOTO CO., INC. (JP) 2025-12-04 US disclosed
US-20250302985-A1 COMPOUND HAVING AFFINITY SUBSTANCE TO ANTIBODY AND BIOORTHOGONAL FUNCTIONAL GROUP, OR SALT THEREOF AJINOMOTO CO., INC. (JP) 2025-10-02 US disclosed
CN-112261954-B Compounds having affinity substances for antibodies and bio-orthogonalization functional groups or salts thereof 味之素株式会社 2025-06-24 CN disclosed
EP-4406975-A2 COMPOUND HAVING AFFINITY SUBSTANCE TO ANTIBODY AND BIOORTHOGONAL FUNCTIONAL GROUP, OR SALT THEREOF AJINOMOTO CO., INC. (JP) 2024-07-31 EP disclosed
CN-117801107-A Benzazepine derivatives, conjugates containing same and application thereof 上海迪诺医药科技有限公司 2024-04-02 CN disclosed
CN-112261954-A Compound having affinity substance for antibody and bio-orthogonal functional group, or salt thereof 味之素株式会社 2021-01-22 CN disclosed
US-9540424-B2 Serum albumin binding molecules BRISTOL-MYERS SQUIBB COMPANY (US) 2017-01-10 US disclosed
US-9540424-B2 Serum albumin binding molecules BRISTOL-MYERS SQUIBB COMPANY (US) 2017-01-10 US disclosed
EP-0131361-B1 COMPLEX OF BIOLOGICALLY ACTIVE PROTEIN WITH REACTIVE HIGH POLYMER HAVING BONDED THERETO BIFUNCTIONAL CHELATE SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1989-10-18 EP disclosed
EP-0310413-A2 Immobilized antibodies NIHON CHEMICAL RESEARCH KABUSHIKI KAISHA also known as JCR PHARMACEUTICALS CO., LTD (JP) 1989-04-05 EP disclosed
US-4652519-A Bifunctional chelating agents and process for their production YEDA RESEARCH AND DEVELOPMENT COMPANY LIMITED (IL) 1987-03-24 US disclosed
EP-0177023-A2 Substance-conjugated complement component C1q The Calpis Food Industry Co., Ltd. (JP) 1986-04-09 EP disclosed
US-4556689-A POLYSUCCINIMIDE WITH BONDED AMINE RESIDUE OR DISULFIDE COMPOUND SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1985-12-03 US disclosed
US-4536391-A REACTING A PLASMIN HEAVY CHAIN WITH UROKINASE IN THE PRESENCE OF A COUPLING AGENT OTSUKA PHARMACEUTICAL CO. (JP) 1985-08-20 US disclosed
EP-0131361-A2 Complex of biologically active protein with reactive high polymer having bonded thereto bifunctional chelate SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1985-01-16 EP disclosed
EP-0109653-A2 Process for preparing urokinase complex OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1984-05-30 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250302985-A1 COMPOUND HAVING AFFINITY SUBSTANCE TO ANTIBODY AND BIOORTHOGONAL FUNCTIONAL GROUP, OR SALT THEREOF FCGR3B, SIGLEC7, SIGLEC9 PTGS1 3257/4885PTGS2 3447/4885MGLL 379/4885
US-20250367317-A1 COMPOUND HAVING AFFINITY SUBSTANCE TO ANTIBODY AND BIOORTHOGONAL FUNCTIONAL GROUP, OR SALT THEREOF FCGR3B, SIGLEC7, SIGLEC9 PTGS1 3257/4885PTGS2 3447/4885MGLL 379/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.