Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLPP | Q16740 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3034549 | 1.00 | CLPP (0.44) | CLPPMAPTGAAMAPK1LMNA | |
| SCHEMBL781369 | 0.79 | CLPP (0.53) | CLPPMAPTGAAMAPK1KMT2A | |
| SCHEMBL781368 | 0.79 | CLPP (0.53) | CLPPMAPTGAAMAPK1KMT2A | |
| SCHEMBL9755625 | 0.78 | GAA (0.46) | MAPTGAALMNAMEN1KMT2A | |
| SCHEMBL11602108 | 0.77 | MAPT (0.52) | MAPTGAALMNAMEN1KMT2A | |
| SCHEMBL13753323 | 0.73 | MAPT (0.49) | MAPTGAALMNAALDH1A1CYP2D6 | |
| SCHEMBL985997 | 0.73 | LARS1 (0.58) | MEN1KMT2ARAB9A | |
| Hydrochloric Acid SCHEMBL8669233 | 0.72 | LARS1 (0.57) | MEN1KMT2ARAB9A | |
| SCHEMBL7298409 | 0.71 | LARS1 (0.56) | MAPTALDH1A1HPGDSMN1; SMN2TDP1 | |
| SCHEMBL17822181 | 0.71 | LARS1 (0.56) | MAPTALDH1A1HPGDSMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010068794-A2 | HIF INHIBITORS AND USE THEREOF | THE GENERAL HOSPITAL CORPORATION (US) | 2010-06-17 | — | — | WO | claimed |
| WO-2010068794-A2 | HIF INHIBITORS AND USE THEREOF | THE GENERAL HOSPITAL CORPORATION (US) | 2010-06-17 | — | — | WO | disclosed |