Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLPP | Q16740 | 2/20 | 0.53 |
| ▸ | HPGDS | O60760 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 3/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 3/20 | 0.46 |
| ▸ | EEF1A1 | P68104 | 1/20 | 0.45 |
| ▸ | EEF1A2 | Q05639 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | GRN | P28799 | 1/20 | 0.44 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | F3 | P13726 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL781369 | 1.00 | CLPP (0.53) | CLPPHPGDSCA1CA12CA9 | |
| SCHEMBL3034549 | 0.79 | CLPP (0.44) | CLPPALDH1A1KMT2AGAAHPGD | |
| SCHEMBL3034546 | 0.79 | CLPP (0.44) | CLPPALDH1A1KMT2AGAAHPGD | |
| SCHEMBL457080 | 0.78 | ALDH1A1 (0.56) | CLPPHPGDSCA1CA12CA9 | |
| SCHEMBL455429 | 0.78 | ALDH1A1 (0.56) | CLPPHPGDSCA1CA12CA9 | |
| SCHEMBL455428 | 0.78 | ALDH1A1 (0.56) | CLPPHPGDSCA1CA12CA9 | |
| SCHEMBL31546603 | 0.75 | ALDH1A1 (0.62) | ALDH1A1POLBKMT2AGAAHPGD | |
| SCHEMBL31546643 | 0.75 | ALDH1A1 (0.62) | ALDH1A1POLBKMT2AGAAHPGD | |
| SCHEMBL11602108 | 0.74 | MAPT (0.52) | ALDH1A1POLBKMT2ACA2GAA | |
| SCHEMBL9755640 | 0.74 | ALDH1A1 (0.52) | CLPPHPGDSCA1CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170157111-A1 | HIF INHIBITORS AND USE THEREOF | THE GENERAL HOSPITAL CORPORATION (US) | 2017-06-08 | — | — | US | claimed |
| US-20150023868-A1 | HIF INHIBITORS AND USE THEREOF | THE GENERAL HOSPITAL CORPORATION (US) | 2015-01-22 | — | — | US | claimed |
| US-20120070369-A1 | HIF INHIBITORS AND USE THEREOF | THE GENERAL HOSPITAL CORPORATION (US) | 2012-03-22 | — | — | US | claimed |
| WO-2010068794-A2 | HIF INHIBITORS AND USE THEREOF | THE GENERAL HOSPITAL CORPORATION (US) | 2010-06-17 | — | — | WO | claimed |
| US-10881656-B2 | HIF inhibitors and use thereof | THE GENERAL HOSPITAL CORPORATION (US) | 2021-01-05 | — | — | US | disclosed |
| US-20170157111-A1 | HIF INHIBITORS AND USE THEREOF | THE GENERAL HOSPITAL CORPORATION (US) | 2017-06-08 | — | — | US | disclosed |
| US-9604958-B2 | HIF inhibitors and use thereof | THE GENERAL HOSPITAL CORPORATION (US) | 2017-03-28 | — | — | US | disclosed |
| US-20150023868-A1 | HIF INHIBITORS AND USE THEREOF | THE GENERAL HOSPITAL CORPORATION (US) | 2015-01-22 | — | — | US | disclosed |
| US-20120070369-A1 | HIF INHIBITORS AND USE THEREOF | THE GENERAL HOSPITAL CORPORATION (US) | 2012-03-22 | — | — | US | disclosed |
| WO-2010068794-A2 | HIF INHIBITORS AND USE THEREOF | THE GENERAL HOSPITAL CORPORATION (US) | 2010-06-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10881656-B2 | HIF inhibitors and use thereof | HIF1AN, HIF1A, EGLN3 | CLPP 3576/4885HPGDS 45/4885CA1 2233/4885 |
| US-20120070369-A1 | HIF INHIBITORS AND USE THEREOF | HIF1AN, HIF1A, EGLN3 | CLPP 3576/4885HPGDS 45/4885CA1 2233/4885 |
| US-20150023868-A1 | HIF INHIBITORS AND USE THEREOF | HIF1AN, HIF1A, EGLN3 | CLPP 3576/4885HPGDS 45/4885CA1 2233/4885 |
| US-20170157111-A1 | HIF INHIBITORS AND USE THEREOF | HIF1AN, HIF1A, EGLN3 | CLPP 3576/4885HPGDS 45/4885CA1 2233/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.