Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 1/20 | 0.52 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.52 |
| ▸ | VCP | P55072 | 1/20 | 0.45 |
| ▸ | KHK | P50053 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.44 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | MCOLN2 | Q8IZK6 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3453906 | 0.83 | CHEK1 (0.58) | CHRNB4CHRNA3ACVR1CHEK1 | |
| SCHEMBL13778275 | 0.78 | TGFBR1 (0.54) | KHKKDM4EALDH1A1MAPTPKM | |
| SCHEMBL6357589 | 0.78 | CHEK1 (0.53) | CHRNB4CHRNA3ACVR1CHEK1 | |
| SCHEMBL3453352 | 0.77 | HTR1A (0.66) | CHRNB4CHRNA3TGFBR1 | |
| SCHEMBL27818822 | 0.77 | CHRNB4 (0.52) | CHRNB4CHRNA3ALDH1A1MAPTDRD2 | |
| SCHEMBL15345003 | 0.76 | KDM4E (0.46) | CHRNB4CHRNA3KHKKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL3268024 | 0.76 | HTR1A (0.64) | CHRNB4CHRNA3TGFBR1ACVR1 | |
| SCHEMBL12321710 | 0.75 | CHRNB2 (0.55) | CHRNB4CHRNA3VCPKHKKDM4E | |
| SCHEMBL12326041 | 0.75 | KDM4E (0.45) | VCPKHKKDM4EALDH1A1MAPT | |
| SCHEMBL13436330 | 0.75 | KDM4E (0.45) | VCPKHKKDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2233470-A1 | Histamine H3 receptor antagonists | High Point Pharmaceuticals, LLC (US) | 2010-09-29 | — | — | EP | disclosed |