Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | STS | P08842 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | THRB | P10828 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22722159 | 1.00 | GPR119 (0.47) | GPR119JAK2JAK1STSKDM4E | |
| SCHEMBL18668633 | 0.90 | RORC (0.46) | GPR119JAK2JAK1STSKDM4E | |
| SCHEMBL29597428 | 0.90 | RORC (0.46) | GPR119JAK2JAK1STSKDM4E | |
| SCHEMBL24276430 | 0.90 | RORC (0.46) | GPR119JAK2JAK1STSKDM4E | |
| SCHEMBL18668635 | 0.90 | RORC (0.46) | GPR119JAK2JAK1STSKDM4E | |
| SCHEMBL20399589 | 0.86 | DRD4 (0.44) | KDM4EMEN1KMT2AGAASMN1; SMN2 | |
| SCHEMBL20399590 | 0.86 | DRD4 (0.44) | KDM4EMEN1KMT2AGAASMN1; SMN2 | |
| SCHEMBL6318216 | 0.82 | GAA (0.45) | GPR119JAK2JAK1STSKDM4E | |
| SCHEMBL6634000 | 0.80 | RORC (0.46) | GPR119JAK2JAK1STSOPRD1 | |
| SCHEMBL6315430 | 0.79 | RORC (0.45) | GPR119JAK2JAK1STSOPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3571198-B1 | BICYCLIC AMINES AS JAK KINASE INHIBITORS | LEO PHARMA AS (DK) | 2023-02-01 | — | — | EP | disclosed |