Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.41 |
| ▸ | JAK3 | P52333 | 3/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | TNIK | Q9UKE5 | 3/20 | 0.40 |
| ▸ | TNF | P01375 | 2/20 | 0.40 |
| ▸ | CCR2 | P41597 | 3/20 | 0.39 |
| ▸ | GHSR | Q92847 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 2/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26516664 | 1.00 | JAK2 (0.41) | JAK2JAK3PTK2KDRTNIK | |
| SCHEMBL30360613 | 0.90 | PIK3CA (0.41) | JAK2JAK3PTK2KDRTNIK | |
| SCHEMBL26516659 | 0.90 | PIK3CA (0.41) | JAK2JAK3PTK2KDRTNIK | |
| SCHEMBL26516654 | 0.88 | CCR2 (0.41) | JAK2JAK3PTK2KDRTNIK | |
| SCHEMBL26119124 | 0.87 | CCR2 (0.47) | JAK2JAK3PTK2CCR2 | |
| SCHEMBL26119662 | 0.87 | OPRM1 (0.41) | JAK2JAK3PTK2KDRTNIK | |
| SCHEMBL26516660 | 0.86 | GPR119 (0.44) | JAK2JAK3PTK2KDR | |
| Ammonia Solution, Strong SCHEMBL29006622 | 0.80 | LRRK2 (0.35) | CCR2GHSRPTGS2 | |
| SCHEMBL29006626 | 0.78 | MAP4K1 (0.47) | JAK2JAK3PTK2PTGS2 | |
| SCHEMBL26123679 | 0.77 | MAP4K4 (0.39) | TNIKPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115956077-A | Substituted heteroaryl compounds as TLR9 inhibitors | 百时美施贵宝公司 | 2023-04-11 | — | — | CN | claimed |