SCHEMBL30360770

SCHEMBL30360770

C=CCc1ccccc1Oc1cccc(C#N)c1C#N

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.40
ALDH1A1 P00352 3/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
ICAM1 P05362 1/20 0.37
SELE P16581 1/20 0.37
VCAM1 P19320 1/20 0.37
HTR1A P08908 2/20 0.36
ADRA2C P18825 2/20 0.36
ADRA2A P08913 1/20 0.36
ADRA2B P18089 1/20 0.36
NISCH Q9Y2I1 1/20 0.36
ADRB2 P07550 3/20 0.35
ADRB1 P08588 3/20 0.35
LMNA P02545 2/20 0.35
ADRB3 P13945 1/20 0.35
SLC6A2 P23975 1/20 0.35
BDKRB2 P30411 1/20 0.35
SLC6A4 P31645 1/20 0.35
ADRA1A P35348 1/20 0.35
HTR2B P41595 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20510894 1.00 KDM4E (0.40) KDM4EALDH1A1SMN1; SMN2ICAM1SELE
SCHEMBL30360759 0.83 TSHR (0.35) KDM4EALDH1A1SMN1; SMN2ADRA2CADRA2A
SCHEMBL20511171 0.83 TSHR (0.35) KDM4EALDH1A1SMN1; SMN2ADRA2CADRA2A
SCHEMBL8655295 0.81 GABRA1 (0.43) KDM4EALDH1A1SMN1; SMN2GABRA1GABRB2
SCHEMBL31185609 0.81 GABRA1 (0.43) KDM4EALDH1A1SMN1; SMN2GABRA1GABRB2
Water SCHEMBL8939878 0.81 ALDH1A1 (0.49) KDM4EALDH1A1ICAM1SELEVCAM1
SCHEMBL8626899 0.79 SMN1; SMN2 (0.50) KDM4EALDH1A1SMN1; SMN2LMNATSHR
SCHEMBL9123978 0.79 SMN1; SMN2 (0.49) KDM4EALDH1A1SMN1; SMN2LMNATSHR
SCHEMBL29387985 0.79 SMN1; SMN2 (0.49) KDM4EALDH1A1SMN1; SMN2LMNATSHR
SCHEMBL88415 0.79 ALDH1A1 (0.50) KDM4EALDH1A1ICAM1SELEVCAM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110461814-B Resin blends, prepregs and articles containing a phthalonitrile reactive diluent and a bisphthalonitrile resin 3M创新有限公司 2023-04-14 CN disclosed