Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 13/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 11/20 | 0.46 |
| ▸ | SRC | P12931 | 4/20 | 0.43 |
| ▸ | HCK | P08631 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30363553 | 0.90 | RET (0.49) | RETFGFR1FGFR2KDRSRC | |
| SCHEMBL21528023 | 0.90 | RET (0.49) | RETFGFR1FGFR2KDRSRC | |
| SCHEMBL30405924 | 0.85 | RET (0.52) | RETFGFR1FGFR2KDRSRC | |
| SCHEMBL23157800 | 0.78 | RET (0.55) | RETFGFR1FGFR2KDRSRC | |
| SCHEMBL29669709 | 0.78 | RET (0.55) | RETFGFR1FGFR2KDRSRC | |
| SCHEMBL20553584 | 0.78 | RET (0.58) | RETFGFR1FGFR2KDRSRC | |
| SCHEMBL30405647 | 0.77 | TGFBR1 (0.56) | RETKDR | |
| SCHEMBL17595914 | 0.75 | RET (0.51) | RETFGFR1FGFR2KDRSRC | |
| SCHEMBL28353780 | 0.75 | RET (0.56) | RETFGFR1FGFR2KDRSRC | |
| SCHEMBL23150479 | 0.74 | FGFR1 (0.45) | RETFGFR1FGFR2KDRSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4168002-A1 | METHODS FOR DELAYING, PREVENTING, AND TREATING ACQUIRED RESISTANCE TO RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2023-04-26 | — | — | EP | disclosed |