Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 9/20 | 0.36 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23363821 | 1.00 | MAPKAPK2 (0.36) | MAPKAPK2HTR4MAPK1GAAKDM4E | |
| SCHEMBL26522281 | 0.81 | MAPKAPK2 (0.36) | MAPKAPK2GAAKDM4EALDH1A1LMNA | |
| SCHEMBL30364099 | 0.81 | MAPKAPK2 (0.36) | MAPKAPK2GAAKDM4EALDH1A1LMNA | |
| SCHEMBL23363903 | 0.75 | VCAM1 (0.40) | MAPK1ALDH1A1HPGD | |
| SCHEMBL25213075 | 0.75 | HTR2A (0.37) | GAA | |
| SCHEMBL23363798 | 0.75 | GAA (0.33) | HTR4GAA | |
| SCHEMBL27221599 | 0.74 | MAPKAPK2 (0.36) | MAPKAPK2GAAKDM4EALDH1A1LMNA | |
| SCHEMBL29934754 | 0.73 | KDM4E (0.42) | MAPK1GAAKDM4EALDH1A1LMNA | |
| SCHEMBL23363867 | 0.73 | KDM4E (0.42) | MAPK1GAAKDM4EALDH1A1LMNA | |
| SCHEMBL5035685 | 0.72 | HTR4 (0.41) | HTR4MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116262759-B | Pyrimidine tricyclic compound, and preparation method and medical application thereof | 华润医药研究院（深圳）有限公司 | 2023-12-08 | — | — | CN | disclosed |
| CN-116262759-A | Pyrimidine tricyclic compound, and preparation method and medical application thereof | 华润医药研究院（深圳）有限公司 | 2023-06-16 | — | — | CN | disclosed |
| CN-116234797-A | Heterocyclic inhibitors of TEAD for the treatment of cancer | 基因泰克公司 | 2023-06-06 | — | — | CN | disclosed |
| EP-4185386-A1 | HETEROCYCLIC INHIBITORS OF TEAD FOR TREATING CANCER | Genentech, Inc. (US) | 2023-05-31 | — | — | EP | disclosed |