SCHEMBL30367209

SCHEMBL30367209

CC(C)C(=O)N1CCC(c2cc(-c3ccc(NC(=O)c4cccn(-c5ccccn5)c4=O)cc3)c3c(N)nn(C)c3c2)CC1

nearest known ligand 0.52

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
MERTK Q12866 11/20 0.52
TYRO3 Q06418 11/20 0.49
AXL P30530 3/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29052469 1.00 MERTK (0.52) MERTKTYRO3AXL
SCHEMBL29052440 0.91 TYRO3 (0.51) MERTKTYRO3
SCHEMBL30367373 0.91 TYRO3 (0.47) MERTKTYRO3AXL
SCHEMBL29052459 0.88 TYRO3 (0.55) MERTKTYRO3AXL
SCHEMBL30367626 0.88 TYRO3 (0.55) MERTKTYRO3AXL
SCHEMBL30367099 0.86 TYRO3 (0.68) MERTKTYRO3AXL
SCHEMBL29052478 0.86 TYRO3 (0.68) MERTKTYRO3AXL
SCHEMBL30499552 0.85 MERTK (0.40) MERTKTYRO3AXL
SCHEMBL30367687 0.78 MET (0.51) MERTKTYRO3AXL
SCHEMBL30367384 0.77 MAPK1 (0.40) MERTKTYRO3AXL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023155886-A1 PYRAZOLOPYRIDINE COMPOUNDS AS TAM INHIBITORS SHANGHAI ANTENGENE CORPORATION LIMITED (CN) 2023-08-24 WO disclosed
CN-116437918-A Pyrazolopyridine compounds as TAM inhibitors 上海德琪医药科技有限公司 2023-07-14 CN disclosed
WO-2023051464-A1 PYRAZOLOPYRIDINE COMPOUNDS AS TAM INHIBITORS SHANGHAI ANTENGENE CORPORATION LIMITED (CN) 2023-04-06 WO disclosed